7S4F

Protein Tyrosine Phosphatase 1B - F182Q mutant bound with Hepes

Summary for 7S4F

Entry DOI	10.2210/pdb7s4f/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 1, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... (5 entities in total)
Functional Keywords	hydrolase, p-loop, wpd-loops, hepes, protein phosphatase, egfr receptor, phosphoprotein, structural protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35148.32
Authors	Brandao, T.A.S.,Hengge, A.C.,Johnson, S.J. (deposition date: 2021-09-08, release date: 2022-09-21, Last modification date: 2023-10-25)
Primary citation	Shen, R.,Crean, R.M.,Olsen, K.J.,Corbella, M.,Calixto, A.R.,Richan, T.,Brandao, T.A.S.,Berry, R.D.,Tolman, A.,Loria, J.P.,Johnson, S.J.,Kamerlin, S.C.L.,Hengge, A.C. Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13:13524-13540, 2022 Cited by PubMed: 36507179 DOI: 10.1039/d2sc04135a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation