8T72

Crystal structure of WT KRAS4a with bound GMPPNP and Mg ion

Summary for 8T72

• Entry DOI: 10.2210/pdb8t72/pdb
• Related: 8T71
• Descriptor: GTPase KRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: ras, kras, oncoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 62942.18

Authors

Tran, T.H.,Whitley, M.J.,Dharmaiah, S.,Simanshu, D.K. (deposition date: 2023-06-19, release date: 2024-02-14, Last modification date: 2024-02-28)

• Primary citation: Whitley, M.J.,Tran, T.H.,Rigby, M.,Yi, M.,Dharmaiah, S.,Waybright, T.J.,Ramakrishnan, N.,Perkins, S.,Taylor, T.,Messing, S.,Esposito, D.,Nissley, D.V.,McCormick, F.,Stephen, A.G.,Turbyville, T.,Cornilescu, G.,Simanshu, D.K.; Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties.; Sci Adv, 10:eadj4137-eadj4137, 2024; PubMed: 38354232; DOI: 10.1126/sciadv.adj4137

Experimental method

X-RAY DIFFRACTION (1.6 Å)