4MPE
 
 | | Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS8 | | Descriptor: | 4-[(5-hydroxy-1,3-dihydro-2H-isoindol-2-yl)sulfonyl]benzene-1,3-diol, L(+)-TARTARIC ACID, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, ... | | Authors: | Gui, W.J, Tso, S.C, Chuang, J.L, Wu, C.Y, Qi, X, Tambar, U.K, Wynn, R.M, Chuang, D.T. | | Deposit date: | 2013-09-12 | | Release date: | 2014-01-01 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.953 Å) | | Cite: | Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket.
J.Biol.Chem., 289, 2014
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1S40
 | | SOLUTION STRUCTURE OF THE CDC13 DNA-BINDING DOMAIN COMPLEXED WITH A SINGLE-STRANDED TELOMERIC DNA 11-MER | | Descriptor: | 5'-D(*GP*TP*GP*TP*GP*GP*GP*TP*GP*TP*G)-3', Cell division control protein 13 | | Authors: | Mitton-Fry, R.M, Anderson, E.M, Theobald, D.L, Glustrom, L.W, Wuttke, D.S. | | Deposit date: | 2004-01-14 | | Release date: | 2004-05-04 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structural basis for telomeric single-stranded DNA recognition by yeast Cdc13
J.Mol.Biol., 338, 2004
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1S8L
 | | Anion-free form of the D85S mutant of bacteriorhodopsin from crystals grown in the presence of halide | | Descriptor: | 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, Bacteriorhodopsin precursor, RETINAL | | Authors: | Facciotti, M.T, Cheung, V.S, Lunde, C.S, Rouhani, S, Baliga, N.S, Glaeser, R.M. | | Deposit date: | 2004-02-02 | | Release date: | 2004-06-08 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Specificity of anion binding in the substrate pocket of bacteriorhodopsin.
Biochemistry, 43, 2004
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1ST9
 | | Crystal Structure of a Soluble Domain of ResA in the Oxidised Form | | Descriptor: | 1,2-ETHANEDIOL, Thiol-disulfide oxidoreductase resA | | Authors: | Crow, A, Acheson, R.M, Le Brun, N.E, Oubrie, A. | | Deposit date: | 2004-03-25 | | Release date: | 2004-05-11 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural Basis of Redox-coupled Protein Substrate Selection by the Cytochrome c Biosynthesis Protein ResA.
J.Biol.Chem., 279, 2004
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1PX0
 | | Crystal structure of the haloalcohol dehalogenase HheC complexed with the haloalcohol mimic (R)-1-para-nitro-phenyl-2-azido-ethanol | | Descriptor: | (R)-1-PARA-NITRO-PHENYL-2-AZIDO-ETHANOL, halohydrin dehalogenase | | Authors: | de Jong, R.M, Tiesinga, J.J.W, Rozeboom, H.J, Kalk, K.H, Tang, L, Janssen, D.B, Dijkstra, B.W. | | Deposit date: | 2003-07-02 | | Release date: | 2003-10-07 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure and Mechanism of a Bacterial Haloalcohol Dehalogenase: a new variation of the short-chain dehydrogenase/reductase fold without an NAD(P)H binding site
EMBO J., 22, 2003
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1PNV
 | | Crystal Structure of TDP-epi-Vancosaminyltransferase GtfA in complexes with TDP and Vancomycin | | Descriptor: | GLYCOSYLTRANSFERASE GTFA, THYMIDINE-5'-DIPHOSPHATE, VANCOMYCIN, ... | | Authors: | Mulichak, A.M, Losey, H.C, Lu, W, Wawrzak, Z, Walsh, C.T, Garavito, R.M. | | Deposit date: | 2003-06-13 | | Release date: | 2003-08-12 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of the Tdp-Epi-Vancosaminyltransferase Gtfa from the Chloroeremomycin Biosynthetic Pathway.
Proc.Natl.Acad.Sci.USA, 100, 2003
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1VCA
 | | CRYSTAL STRUCTURE OF AN INTEGRIN-BINDING FRAGMENT OF VASCULAR CELL ADHESION MOLECULE-1 AT 1.8 ANGSTROMS RESOLUTION | | Descriptor: | HUMAN VASCULAR CELL ADHESION MOLECULE-1 | | Authors: | Jones, E.Y, Harlos, K, Bottomley, M.J, Robinson, R.C, Driscoll, P.C, Edwards, R.M, Clements, J.M, Dudgeon, T.J, Stuart, D.I. | | Deposit date: | 1995-03-21 | | Release date: | 1995-09-15 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution.
Nature, 373, 1995
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1SQG
 | | The crystal structure of the E. coli Fmu apoenzyme at 1.65 A resolution | | Descriptor: | SUN protein | | Authors: | Foster, P.G, Nunes, C.R, Greene, P, Moustakas, D, Stroud, R.M. | | Deposit date: | 2004-03-18 | | Release date: | 2004-05-18 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | The First Structure of an RNA m5C Methyltransferase,
Fmu, Provides Insight into Catalytic Mechanism
and Specific Binding of RNA Substrate
Structure, 11, 2003
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1FFH
 | | N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS | | Descriptor: | FFH, MAGNESIUM ION | | Authors: | Freymann, D.M, Keenan, R.J, Stroud, R.M, Walter, P. | | Deposit date: | 1996-12-30 | | Release date: | 1997-12-31 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structure of the conserved GTPase domain of the signal recognition particle.
Nature, 385, 1997
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2RKD
 | | The Structure of rat cytosolic PEPCK in complex with 3-phosphonopropionate | | Descriptor: | 3-PHOSPHONOPROPANOIC ACID, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ... | | Authors: | Sullivan, S.M, Stiffin, R.M, Carlson, G.M, Holyoak, T. | | Deposit date: | 2007-10-16 | | Release date: | 2008-01-29 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Differential Inhibition of Cytosolic PEPCK by Substrate Analogues. Kinetic and Structural Characterization of Inhibitor Recognition.
Biochemistry, 47, 2008
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2VCM
 | | Isopenicillin N synthase with substrate analogue AsMCOV | | Descriptor: | FE (II) ION, ISOPENICILLIN N SYNTHETASE, N^6^-[(1R,2S)-1-({[(1R)-1-carboxy-2-methylpropyl]oxy}carbonyl)-2-sulfanylpropyl]-6-oxo-L-lysine, ... | | Authors: | Ge, W, Clifton, I.J, Adlington, R.M, Baldwin, J.E, Rutledge, P.J. | | Deposit date: | 2007-09-25 | | Release date: | 2008-11-04 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural Studies on the Reaction of Isopenicillin N Synthase with a Sterically Demanding Depsipeptide Substrate Analogue.
Chembiochem, 10, 2009
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1SQF
 | | The crystal structure of E. coli Fmu binary complex with S-Adenosylmethionine at 2.1 A resolution | | Descriptor: | S-ADENOSYLMETHIONINE, SUN protein | | Authors: | Foster, P.G, Nunes, C.R, Greene, P, Moustakas, D, Stroud, R.M. | | Deposit date: | 2004-03-18 | | Release date: | 2004-05-18 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The First Structure of an RNA m5C Methyltransferase,
Fmu, Provides Insight into Catalytic Mechanism
and Specific Binding of RNA Substrate
Structure, 11, 2003
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1GKX
 | | Branched-chain alpha-ketoacid dehydrogenase kinase (BCK) | | Descriptor: | CHLORIDE ION, [3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE | | Authors: | Machius, M, Chuang, J.L, Wynn, R.M, Tomchick, D.R, Chuang, D.T. | | Deposit date: | 2001-08-21 | | Release date: | 2001-10-11 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of Rat Bckd Kinase: Nucleotide-Induced Domain Communication in a Mitochondrial Protein Kinase.
Proc.Natl.Acad.Sci.USA, 98, 2001
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1SE7
 | | Solution structure of the E. coli bacteriophage P1 encoded HOT protein: a homologue of the theta subunit of E. coli DNA polymerase III | | Descriptor: | HOMOLOGUE OF THE THETA SUBUNIT OF DNA POLYMERASE III | | Authors: | DeRose, E.F, Kirby, T.W, Mueller, G.A, Chikova, A.K, Schaaper, R.M, London, R.E. | | Deposit date: | 2004-02-16 | | Release date: | 2004-12-14 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Phage Like It HOT: Solution Structure of the Bacteriophage P1-Encoded HOT Protein, a Homolog of the theta Subunit of E. coli DNA Polymerase III
Structure, 12, 2004
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2RK8
 | | The Structure of rat cytosolic PEPCK in complex with phosphonoformate | | Descriptor: | DI(HYDROXYETHYL)ETHER, FORMIC ACID, MANGANESE (II) ION, ... | | Authors: | Sullivan, S.M, Stiffin, R.M, Carlson, G.M, Holyoak, T. | | Deposit date: | 2007-10-16 | | Release date: | 2008-01-29 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Differential Inhibition of Cytosolic PEPCK by Substrate Analogues. Kinetic and Structural Characterization of Inhibitor Recognition.
Biochemistry, 47, 2008
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6LXD
 | | Pri-miRNA bound DROSHA-DGCR8 complex | | Descriptor: | Microprocessor complex subunit DGCR8, RNA (102-mer), Ribonuclease 3, ... | | Authors: | Jin, W, Wang, J, Liu, C.P, Wang, H.W, Xu, R.M. | | Deposit date: | 2020-02-10 | | Release date: | 2020-04-15 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural Basis for pri-miRNA Recognition by Drosha.
Mol.Cell, 78, 2020
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1X7T
 | | Structure of TTR R104H: a non-amyloidogenic variant with protective clinical effects | | Descriptor: | Transthyretin | | Authors: | Neto-Silva, R.M, Macedo-Ribeiro, S, Pereira, P.J.B, Coll, M, Saraiva, M.J, Damas, A.M. | | Deposit date: | 2004-08-16 | | Release date: | 2005-03-22 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | X-ray crystallographic studies of two transthyretin variants: further insights into amyloidogenesis.
Acta Crystallogr.,Sect.D, 61, 2005
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1X93
 | | NMR Structure of Helicobacter pylori HP0222 | | Descriptor: | hypothetical protein HP0222 | | Authors: | Popescu, A, Karpay, A, Israel, D, Peek Jr, R.M, Krezel, A.M. | | Deposit date: | 2004-08-19 | | Release date: | 2005-03-22 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Helicobacter pylori protein HP0222 belongs to Arc/MetJ family of transcriptional regulators.
Proteins, 59, 2005
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1JG0
 | | Crystal structure of Escherichia coli thymidylate synthase complexed with 2'-deoxyuridine-5'-monophosphate and N,O-didansyl-L-tyrosine | | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, N,O-DIDANSYL-L-TYROSINE, thymidylate synthase | | Authors: | Fritz, T.A, Tondi, D, Finer-Moore, J.S, Costi, M.P, Stroud, R.M. | | Deposit date: | 2001-06-22 | | Release date: | 2002-02-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.
Chem.Biol., 8, 2001
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1JMK
 | | Structural Basis for the Cyclization of the Lipopeptide Antibiotic Surfactin by the Thioesterase Domain SrfTE | | Descriptor: | SULFATE ION, Surfactin Synthetase | | Authors: | Bruner, S.D, Weber, T, Kohli, R.M, Schwarzer, D, Marahiel, M.A, Walsh, C.T, Stubbs, M.T. | | Deposit date: | 2001-07-18 | | Release date: | 2002-03-27 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE.
Structure, 10, 2002
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1JV6
 | | BACTERIORHODOPSIN D85S/F219L DOUBLE MUTANT AT 2.00 ANGSTROM RESOLUTION | | Descriptor: | 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, Bacteriorhodopsin, RETINAL | | Authors: | Rouhani, S, Cartailler, J.-P, Facciotti, M.T, Walian, P, Needleman, R, Lanyi, J.K, Glaeser, R.M, Luecke, H. | | Deposit date: | 2001-08-28 | | Release date: | 2001-10-31 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of the D85S mutant of bacteriorhodopsin: model of an O-like photocycle intermediate.
J.Mol.Biol., 313, 2001
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4PW6
 | | structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex II | | Descriptor: | 5hmC-containing DNA1, 5hmC-containing DNA2, E3 ubiquitin-protein ligase UHRF2 | | Authors: | Zhou, T, Xiong, J, Wang, M, Yang, N, Wong, J, Zhu, B, Xu, R.M. | | Deposit date: | 2014-03-18 | | Release date: | 2014-05-07 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.789 Å) | | Cite: | Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2.
Mol.Cell, 54, 2014
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4PW5
 | | structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex I | | Descriptor: | 5hmC-containing DNA1, 5hmC-containing DNA2, E3 ubiquitin-protein ligase UHRF2 | | Authors: | ZHou, T, Xiong, J, Wang, M, Yang, N, Wong, J, Zhu, B, Xu, R.M. | | Deposit date: | 2014-03-18 | | Release date: | 2014-05-07 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.204 Å) | | Cite: | Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2.
Mol.Cell, 54, 2014
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2O1W
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4MPC
 | | Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS2 | | Descriptor: | 4-(isoindolin-2-ylsulfonyl)benzene-1,3-diol, L(+)-TARTARIC ACID, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, ... | | Authors: | Gui, W.J, Tso, S.C, Chuang, J.L, Wu, C.Y, Qi, X, Tambar, U.K, Wynn, R.M, Chuang, D.T. | | Deposit date: | 2013-09-12 | | Release date: | 2014-01-01 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.699 Å) | | Cite: | Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket.
J.Biol.Chem., 289, 2014
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