Crystal structure of Escherichia coli thymidylate synthase complexed with 2'-deoxyuridine-5'-monophosphate and N,O-didansyl-L-tyrosine

Summary for 1JG0

Descriptorthymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, N,O-DIDANSYL-L-TYROSINE, ... (4 entities in total)
Functional Keywordsthymidylate synthase, didansyl tyrosine, transferase
Biological sourceEscherichia coli
Cellular locationCytoplasm P0A884
Total number of polymer chains2
Total molecular weight62686.75
Fritz, T.A.,Tondi, D.,Finer-Moore, J.S.,Costi, M.P.,Stroud, R.M. (deposition date: 2001-06-22, release date: 2002-02-08, Last modification date: 2011-07-13)
Primary citation
Fritz, T.A.,Tondi, D.,Finer-Moore, J.S.,Costi, M.P.,Stroud, R.M.
Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.
Chem.Biol., 8:981-995, 2001
PubMed: 11590022 (PDB entries with the same primary citation)
DOI: 10.1016/S1074-5521(01)00067-9
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers110.8%3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-09-16