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PDB: 2921 results

7OSK
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BU of 7osk by Molmil
Ignisphaera aggregans GH53 catalytic domain
Descriptor: Arabinogalactan endo-1,4-beta-galactosidase, CALCIUM ION, CHLORIDE ION, ...
Authors:Fredslund, F, Lo Leggio, L, Poulsen, J.C, Rasmussen, K.K, Muderspach, S, Krogh, K.B.R.M, Jensen, K.
Deposit date:2021-06-08
Release date:2021-09-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Engineering the substrate binding site of the hyperthermostable archaeal endo-beta-1,4-galactanase from Ignisphaera aggregans.
Biotechnol Biofuels, 14, 2021
1YYQ
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BU of 1yyq by Molmil
Y305F Trichodiene Synthase complexed with pyrophosphate
Descriptor: MAGNESIUM ION, PYROPHOSPHATE 2-, Trichodiene synthase
Authors:Vedula, L.S, Rynkiewicz, M.J, Pyun, H.J, Coates, R.M, Cane, D.E, Christianson, D.W.
Deposit date:2005-02-25
Release date:2005-03-29
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular Recognition of the Substrate Diphosphate Group Governs Product Diversity in Trichodiene Synthase Mutants.
Biochemistry, 44, 2005
6JN2
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BU of 6jn2 by Molmil
Crystal structure of the coiled-coil domains of human DOT1L in complex with AF10
Descriptor: Histone-lysine N-methyltransferase, H3 lysine-79 specific, Protein AF-10
Authors:Song, X, Wang, M, Yang, N, Xu, R.M.
Deposit date:2019-03-13
Release date:2019-09-18
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:A higher-order configuration of the heterodimeric DOT1L-AF10 coiled-coil domains potentiates their leukemogenenic activity.
Proc.Natl.Acad.Sci.USA, 116, 2019
3C02
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BU of 3c02 by Molmil
X-ray structure of the aquaglyceroporin from Plasmodium falciparum
Descriptor: Aquaglyceroporin, GLYCEROL, octyl beta-D-glucopyranoside
Authors:Newby, Z.E, Stroud, R.M, Center for Structures of Membrane Proteins (CSMP)
Deposit date:2008-01-18
Release date:2008-05-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum.
Nat.Struct.Mol.Biol., 15, 2008
1ZMT
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BU of 1zmt by Molmil
Structure of haloalcohol dehalogenase HheC of Agrobacterium radiobacter AD1 in complex with (R)-para-nitro styrene oxide, with a water molecule in the halide-binding site
Descriptor: (R)-PARA-NITROSTYRENE OXIDE, Haloalcohol dehalogenase HheC
Authors:de Jong, R.M, Tiesinga, J.J.W, Villa, A, Tang, L, Janssen, D.B, Dijkstra, B.W.
Deposit date:2005-05-10
Release date:2005-10-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis for the Enantioselectivity of an Epoxide Ring Opening Reaction Catalyzed by Halo Alcohol Dehalogenase HheC.
J.Am.Chem.Soc., 127, 2005
1YYR
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BU of 1yyr by Molmil
Y305F Trichodiene Synthase: Complex With Mg, Pyrophosphate, and (4R)-7-azabisabolene
Descriptor: (1S)-N,4-DIMETHYL-N-(4-METHYLPENT-3-ENYL)CYCLOHEX-3-ENAMINIUM, 1,2-ETHANEDIOL, MAGNESIUM ION, ...
Authors:Vedula, L.S, Rynkiewicz, M.J, Pyun, H.J, Coates, R.M, Cane, D.E, Christianson, D.W.
Deposit date:2005-02-25
Release date:2005-03-29
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular Recognition of the Substrate Diphosphate Group Governs Product Diversity in Trichodiene Synthase Mutants.
Biochemistry, 44, 2005
3NTH
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BU of 3nth by Molmil
Crystal structure of Tudor and Aubergine [R13(me2s)] complex
Descriptor: Maternal protein tudor, peptide from Aubergine
Authors:Liu, H.P, Huang, Y, Li, Z.Z, Gong, W.M, Xu, R.M.
Deposit date:2010-07-05
Release date:2010-09-15
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for methylarginine-dependent recognition of Aubergine by Tudor
Genes Dev., 24, 2010
4UY3
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BU of 4uy3 by Molmil
Cytoplasmic domain of bacterial cell division protein ezra
Descriptor: SEPTATION RING FORMATION REGULATOR EZRA
Authors:Cleverley, R.M, Barrett, J.R, Basle, A, Khai-Bui, N, Hewitt, L, Solovyova, A, Xu, Z, Daniela, R.A, Dixon, N.E, Harry, E.J, Oakley, A.J, Vollmer, W, Lewis, R.J.
Deposit date:2014-08-28
Release date:2014-10-22
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and Function of a Spectrin-Like Regulator of Bacterial Cytokinesis.
Nat.Commun., 5, 2014
2AE9
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BU of 2ae9 by Molmil
Solution Structure of the theta subunit of DNA polymerase III from E. coli
Descriptor: DNA polymerase III, theta subunit
Authors:Mueller, G.A, Kirby, T.W, Derose, E.F, Li, D, Schaaper, R.M, London, R.E.
Deposit date:2005-07-21
Release date:2005-10-18
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Nuclear Magnetic Resonance Solution Structure of the Escherichia coli DNA Polymerase III {theta} Subunit.
J.Bacteriol., 187, 2005
4ISK
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BU of 4isk by Molmil
Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2'-deoxy-5'-uridylic acid, MAGNESIUM ION, ...
Authors:Tochowicz, A, Finer-Moore, J, Stroud, R.M.
Deposit date:2013-01-16
Release date:2013-12-25
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (1.752 Å)
Cite:Development and Binding Mode Assessment of N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-gamma-glutamyl-d-glutamic Acid (BGC 945), a Novel Thymidylate Synthase Inhibitor That Targets Tumor Cells.
J.Med.Chem., 56, 2013
1ZW9
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BU of 1zw9 by Molmil
Yeast HSP82 in complex with the Novel HSP90 Inhibitor 8-(6-Bromo-benzo[1,3]dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)-adenine
Descriptor: 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE, HSP82
Authors:Immormino, R.M, Gewirth, D.T, Chiosis, G.
Deposit date:2005-06-03
Release date:2006-06-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibitory Ligands Adopt Different Conformations When Bound to Hsp90 or GRP94: Implications for Paralog-specific Drug Design
To be Published
7OPQ
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BU of 7opq by Molmil
Rab27a fusion with Slp2a-RBDa1 effector covalent adduct with CA1 in C188
Descriptor: 1-[(2~{S})-2-(4-methoxyphenyl)pyrrolidin-1-yl]propan-1-one, GLYCEROL, MAGNESIUM ION, ...
Authors:Jamshidiha, M, Tersa, M, Lanyon-Hogg, T, Perez-Dorado, I, Sutherell, C.L, De Vita, E, Morgan, R.M.L, Tate, E.W, Cota, E.
Deposit date:2021-06-01
Release date:2022-04-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
Rsc Med Chem, 13, 2022
3OO1
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BU of 3oo1 by Molmil
Structure of E. Coli CheY mutant A113P in the absence of Sulfate
Descriptor: Chemotaxis protein CheY, MAGNESIUM ION
Authors:Immormino, R.M, Bourret, R.B.
Deposit date:2010-08-30
Release date:2011-08-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Exploring the effect of an allosteric site on conformational coupling in CheY
To be Published
7OPR
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BU of 7opr by Molmil
Rab27a fusion with Slp2a-RBDa1 effector covalent adduct with CB1 in C123
Descriptor: GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Jamshidiha, M, Tersa, M, Lanyon-Hogg, T, Perez-Dorado, I, Sutherell, C.L, De Vita, E, Morgan, R.M.L, Tate, E.W, Cota, E.
Deposit date:2021-06-01
Release date:2022-04-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
Rsc Med Chem, 13, 2022
7OPP
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BU of 7opp by Molmil
Crystal structure of the Rab27a fusion with Slp2a-RBDa1 effector for SF4 pocket drug targeting
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Synaptotagmin-like protein 2,Ras-related protein Rab-27A
Authors:Jamshidiha, M, Tersa, M, Lanyon-Hogg, T, Perez-Dorado, I, Sutherell, C.L, De Vita, E, Morgan, R.M.L, Tate, E.W, Cota, E.
Deposit date:2021-06-01
Release date:2022-04-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
Rsc Med Chem, 13, 2022
2LC9
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BU of 2lc9 by Molmil
Solution Structure of a Minor and Transiently Formed State of a T4 Lysozyme Mutant
Descriptor: Lysozyme
Authors:Bouvignies, G, Vallurupalli, P, Hansen, D, Correia, B, Lange, O, Bah, A, Vernon, R.M, Dahlquist, F.W, Baker, D, Kay, L.E.
Deposit date:2011-04-26
Release date:2011-08-17
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution structure of a minor and transiently formed state of a T4 lysozyme mutant.
Nature, 477, 2011
3OO0
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BU of 3oo0 by Molmil
Structure of apo CheY A113P
Descriptor: AMMONIUM ION, Chemotaxis protein CheY, GLYCEROL, ...
Authors:Pazy, Y, Collins, E.J, Guanga, G.P, Miller, P.J, Immormino, R.M, Silversmith, R.E, Bourret, R.B.
Deposit date:2010-08-30
Release date:2011-08-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Exploring the effect of an allosteric site on conformational coupling in CheY
To be Published
4J37
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BU of 4j37 by Molmil
Crystal structure of the catalytic domain of human Pus1
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ...
Authors:Czudnochowski, N, Finer-Moore, J.S, Stroud, R.M.
Deposit date:2013-02-05
Release date:2013-06-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities.
J.Mol.Biol., 425, 2013
3P22
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BU of 3p22 by Molmil
Crystal structure of the ENE, a viral RNA stability element, in complex with A9 RNA
Descriptor: Core ENE hairpin from KSHV PAN RNA, oligo(A)9 RNA
Authors:Mitton-Fry, R.M, DeGregorio, S.J, Wang, J, Steitz, T.A, Steitz, J.A.
Deposit date:2010-10-01
Release date:2010-12-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Poly(A) tail recognition by a viral RNA element through assembly of a triple helix.
Science, 330, 2010
2A9W
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BU of 2a9w by Molmil
E. coli TS complexed with dUMP and inhibitor GA9
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-BROMOPHENOL, 3,3-BIS(3-BROMO-4-HYDROXYPHENYL)-7-CHLORO-1H,3H-BENZO[DE]ISOCHROMEN-1-ONE, ...
Authors:Finer-Moore, J.S, Anderson, A.C, O'Neil, R.H, Costi, M.P, Ferrari, S, Krucinski, J, Stroud, R.M.
Deposit date:2005-07-12
Release date:2005-10-11
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition.
Acta Crystallogr.,Sect.D, 61, 2005
3OY4
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BU of 3oy4 by Molmil
Crystal Structure of HIV-1 L76V Protease in Complex with the Protease Inhibitor Darunavir.
Descriptor: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ACETATE ION, HIV-1 PROTEASE, ...
Authors:Schiffer, C.A, Nalivaika, E.A, Bandaranayake, R.M.
Deposit date:2010-09-22
Release date:2011-02-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Crystal Structure of HIV-1 L76V Protease in Complex with the Protease Inhibitor Darunavir.
To be Published
4WTB
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BU of 4wtb by Molmil
BthTX-I, a svPLA2s-like toxin, complexed with zinc ions
Descriptor: Basic phospholipase A2 homolog bothropstoxin-1, CHLORIDE ION, SULFATE ION, ...
Authors:Borges, R.J, Fontes, M.R.M.
Deposit date:2014-10-29
Release date:2015-11-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Functional and structural studies of a Phospholipase A2-like protein complexed to zinc ions: Insights on its myotoxicity and inhibition mechanism.
Biochim. Biophys. Acta, 1861, 2017
2L9V
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BU of 2l9v by Molmil
NMR structure of the FF domain L24A mutant's folding transition state
Descriptor: Pre-mRNA-processing factor 40 homolog A
Authors:Korzhnev, D.M, Vernon, R.M, Religa, T.L, Hansen, A, Baker, D, Fersht, A.R, Kay, L.E.
Deposit date:2011-02-24
Release date:2011-09-28
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Nonnative interactions in the FF domain folding pathway from an atomic resolution structure of a sparsely populated intermediate: an NMR relaxation dispersion study.
J.Am.Chem.Soc., 133, 2011
2LJB
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BU of 2ljb by Molmil
Structure of the influenza AM2-BM2 chimeric channel
Descriptor: M2 protein, BM2 protein chimera
Authors:Pielak, R.M, Oxenoid, K, Chou, J.J.
Deposit date:2011-09-10
Release date:2011-11-16
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses.
Structure, 19, 2011
4X9E
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BU of 4x9e by Molmil
DEOXYGUANOSINETRIPHOSPHATE TRIPHOSPHOHYDROLASE from Escherichia coli with two DNA effector molecules
Descriptor: Deoxyguanosinetriphosphate triphosphohydrolase, MAGNESIUM ION, RNA (5'-R(P*CP*CP*C)-3')
Authors:Singh, D, Gawel, D, Itsko, M, Krahn, J.M, London, R.E, Schaaper, R.M.
Deposit date:2014-12-11
Release date:2015-02-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of Escherichia coli dGTP Triphosphohydrolase: A HEXAMERIC ENZYME WITH DNA EFFECTOR MOLECULES.
J.Biol.Chem., 290, 2015

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