2GFD

GRP94 in complex with the novel HSP90 Inhibitor Radamide

Summary for 2GFD

Entry DOI	10.2210/pdb2gfd/pdb
Related	1OSF 1QY8 1U0Z 1ZWH 2FXS 2FYP
Descriptor	Endoplasmin, METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE, TETRAETHYLENE GLYCOL, ... (5 entities in total)
Functional Keywords	grp94, hsp82, hsp90, htpg, chaperone, ligand, radicicol, geldanamycin, radester, radamide
Biological source	Canis lupus familiaris (dog) More
Cellular location	Endoplasmic reticulum lumen: P41148
Total number of polymer chains	2
Total formula weight	54866.79
Authors	Immormino, R.M.,Gewirth, D.T. (deposition date: 2006-03-21, release date: 2007-04-03, Last modification date: 2023-08-30)
Primary citation	Immormino, R.M.,Metzger, L.E.,Reardon, P.N.,Dollins, D.E.,Blagg, B.S.,Gewirth, D.T. Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design. J.Mol.Biol., 388:1033-1042, 2009 Cited by PubMed: 19361515 DOI: 10.1016/j.jmb.2009.03.071 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation