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2FYP

GRP94 in complex with the novel HSP90 Inhibitor Radester amine

Summary for 2FYP
Entry DOI10.2210/pdb2fyp/pdb
Related1BGQ 1OSF 1QY8 1U0Z 1YET 1ZWH 2EXL 2FXS
DescriptorEndoplasmin, 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE, TETRAETHYLENE GLYCOL, ... (5 entities in total)
Functional Keywordsgrp94, hsp82, hsp90, htpg, chaperone, ligand, radicicol, geldanamycin, radester, radamide
Biological sourceCanis lupus (dog)
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Cellular locationEndoplasmic reticulum lumen: P41148
Total number of polymer chains2
Total formula weight55615.72
Authors
Immormino, R.M.,Gewirth, D.T. (deposition date: 2006-02-08, release date: 2007-02-06, Last modification date: 2023-08-30)
Primary citationImmormino, R.M.,Gewirth, D.T.,Blagg, B.S.
Inhibittory Ligands Adopt Different Conformations When Bound to Hsp90 or GRP94: Implications for Paralog-specific Drug Design
To be Published,
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

217705

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