2FYP

GRP94 in complex with the novel HSP90 Inhibitor Radester amine

Summary for 2FYP

• Entry DOI: 10.2210/pdb2fyp/pdb
• Related: 1BGQ 1OSF 1QY8 1U0Z 1YET 1ZWH 2EXL 2FXS
• Descriptor: Endoplasmin, 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE, TETRAETHYLENE GLYCOL, ... (5 entities in total)
• Functional Keywords: grp94, hsp82, hsp90, htpg, chaperone, ligand, radicicol, geldanamycin, radester, radamide
• Biological source: Canis lupus (dog); More
• Cellular location: Endoplasmic reticulum lumen: P41148
• Total number of polymer chains: 2
• Total formula weight: 55615.72

Authors

Immormino, R.M.,Gewirth, D.T. (deposition date: 2006-02-08, release date: 2007-02-06, Last modification date: 2023-08-30)

• Primary citation: Immormino, R.M.,Gewirth, D.T.,Blagg, B.S.; Inhibittory Ligands Adopt Different Conformations When Bound to Hsp90 or GRP94: Implications for Paralog-specific Drug Design; To be Published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)