2FYP
GRP94 in complex with the novel HSP90 Inhibitor Radester amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Endoplasmin | polymer | 236 | 26514.0 | 2 | UniProt (P41148) Pfam (PF13589) | Canis lupus (dog) | 94 kDa glucose-regulated protein, GRP94 |
| 2 | C, H (A, B) | 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE | non-polymer | 397.8 | 2 | Chemie (RDE) | |||
| 3 | D, E, F, G, I... (A, B) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 8 | Chemie (PG4) | |||
| 4 | M (B) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 5 | N, O (A, B) | water | water | 18.0 | 365 | Chemie (HOH) |
Sequence modifications
A, B: 69 - 286 (UniProt: P41148)
A, B: 328 - 337 (UniProt: P41148)
| PDB | External Database | Details |
|---|---|---|
| Gly 65 | - | cloning artifact |
| Ser 66 | - | cloning artifact |
| His 67 | - | cloning artifact |
| Met 68 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Gly 324 | - | SEE REMARK 999 |
| Gly 325 | - | SEE REMARK 999 |
| Gly 326 | - | SEE REMARK 999 |
| Gly 327 | - | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 53028.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2587.7 | |
| All* | Total formula weight | 55615.7 |
