2GFD
GRP94 in complex with the novel HSP90 Inhibitor Radamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Endoplasmin | polymer | 236 | 26514.0 | 2 | UniProt (P41148) Pfam (PF13589) | Canis lupus familiaris (dog) | 94 kDa glucose-regulated protein, GRP94 |
| 2 | C, F (A, B) | METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE | non-polymer | 411.8 | 2 | Chemie (RDA) | |||
| 3 | D, E, G, H (A, B) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 4 | Chemie (PG4) | |||
| 4 | I (B) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 284 | Chemie (HOH) |
Sequence modifications
A, B: 69 - 286 (UniProt: P41148)
A, B: 328 - 337 (UniProt: P41148)
| PDB | External Database | Details |
|---|---|---|
| Gly 65 | - | cloning artifact |
| Ser 66 | - | cloning artifact |
| His 67 | - | cloning artifact |
| Met 68 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Gly 287 | - | SEE REMARK 999 |
| Gly 288 | - | SEE REMARK 999 |
| Gly 289 | - | SEE REMARK 999 |
| Gly 290 | - | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 53028.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1838.8 | |
| All* | Total formula weight | 54866.8 |
