2FXS

Yeast HSP82 in complex with the novel HSP90 Inhibitor Radamide

Summary for 2FXS

Entry DOI	10.2210/pdb2fxs/pdb
Related	1A4H 1BGQ 1QY8 1U0Z 1ZWH 2EXL 2FYP
Descriptor	ATP-dependent molecular chaperone HSP82, METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE, GLYCEROL, ... (4 entities in total)
Functional Keywords	hsp82, hsp90, grp94, htpg, chaperone, ligand, radicicol, geldanamycin, radester
Biological source	Saccharomyces cerevisiae (baker's yeast)
Cellular location	Cytoplasm: P02829
Total number of polymer chains	1
Total formula weight	27917.03
Authors	Immormino, R.M.,Gewirth, D.T. (deposition date: 2006-02-06, release date: 2007-02-06, Last modification date: 2023-08-30)
Primary citation	Immormino, R.M.,Metzger, L.E.,Reardon, P.N.,Dollins, D.E.,Blagg, B.S.,Gewirth, D.T. Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design. J.Mol.Biol., 388:1033-1042, 2009 Cited by PubMed: 19361515 DOI: 10.1016/j.jmb.2009.03.071 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation