2FXS

Yeast HSP82 in complex with the novel HSP90 Inhibitor Radamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	ATP-dependent molecular chaperone HSP82	polymer	240	27044.8	1	UniProt (P02829) Pfam (PF02518) In PDB	Saccharomyces cerevisiae (baker's yeast)	Heat shock protein Hsp90 heat-inducible isoform, 82 kDa heat shock protein
2	A	METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE	non-polymer		411.8	1	Chemie (RDA)
3	A	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
4		water	water		18.0	263	Chemie (HOH)

Sequence modifications

A: 1 - 220 (UniProt: P02829)

PDB	External Database	Details
Met -19	-	cloning artifact
Gly -18	-	cloning artifact
Ser -17	-	cloning artifact
Ser -16	-	cloning artifact
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	cloning artifact
Ser -8	-	cloning artifact
Gly -7	-	cloning artifact
Leu -6	-	cloning artifact
Val -5	-	cloning artifact
Pro -4	-	cloning artifact
Arg -3	-	cloning artifact
Gly -2	-	cloning artifact
Ser -1	-	cloning artifact
His 0	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	27044.8
Non-Polymers*	Number of molecules	6
	Total formula weight	872.3
All*	Total formula weight	27917.0

*Water molecules are not included.