2FXS
Yeast HSP82 in complex with the novel HSP90 Inhibitor Radamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ATP-dependent molecular chaperone HSP82 | polymer | 240 | 27044.8 | 1 | UniProt (P02829) Pfam (PF02518) | Saccharomyces cerevisiae (baker's yeast) | Heat shock protein Hsp90 heat-inducible isoform, 82 kDa heat shock protein |
| 2 | B (A) | METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE | non-polymer | 411.8 | 1 | Chemie (RDA) | |||
| 3 | C, D, E, F, G (A) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 4 | H (A) | water | water | 18.0 | 263 | Chemie (HOH) |
Sequence modifications
A: 1 - 220 (UniProt: P02829)
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | cloning artifact |
| Gly -18 | - | cloning artifact |
| Ser -17 | - | cloning artifact |
| Ser -16 | - | cloning artifact |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | cloning artifact |
| Ser -8 | - | cloning artifact |
| Gly -7 | - | cloning artifact |
| Leu -6 | - | cloning artifact |
| Val -5 | - | cloning artifact |
| Pro -4 | - | cloning artifact |
| Arg -3 | - | cloning artifact |
| Gly -2 | - | cloning artifact |
| Ser -1 | - | cloning artifact |
| His 0 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27044.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 872.3 | |
| All* | Total formula weight | 27917.0 |
