Crystal structure of pyruvate dehydrogenase kinase isoform 4 in complex with ADP

Summary for 3D2R

Descriptor[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywordsprotein-nucleotide complex, homodimer, ghkl superfamily, kinase, carbohydrate metabolism, glucose metabolism, mitochondrion, phosphoprotein, transferase, transit peptide
Biological sourceHomo sapiens
Cellular locationMitochondrion matrix Q16654
Total number of polymer chains2
Total molecular weight90637.17
Kato, M.,Wynn, R.M.,Chuang, L.C.,Tso, S.-C.,Li, J.,Chuang, D.T. (deposition date: 2008-05-08, release date: 2008-08-05, Last modification date: 2011-07-13)
Primary citation
Wynn, R.M.,Kato, M.,Chuang, J.L.,Tso, S.C.,Li, J.,Chuang, D.T.
Pyruvate Dehydrogenase Kinase-4 Structures Reveal a Metastable Open Conformation Fostering Robust Core-free Basal Activity.
J.Biol.Chem., 283:25305-25315, 2008
PubMed: 18658136 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M802249200
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23070.1%4.7%5.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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