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PDB: 136 件
3ES5
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Crystal Structure of Partitivirus (PsV-F)
分子名称: Putative capsid protein
著者Pan, J, Dong, L, Lin, L, Ochoa, W.F, Sinkovits, R.S, Havens, W.M, Nibert, M.L, Baker, T.S, Ghabrial, S.A, Tao, Y.J.
登録日2008-10-03
公開日2009-03-10
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Atomic structure reveals the unique capsid organization of a dsRNA virus.
Proc.Natl.Acad.Sci.USA, 106, 2009
7SN1
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Structure of human SARS-CoV-2 neutralizing antibody C1C-A3 Fab
分子名称: neutralizing antibody C1C-A3 Fab heavy chain, neutralizing antibody C1C-A3 Fab light chain
著者Pan, J, Abraham, J, Clark, S.
登録日2021-10-27
公開日2021-12-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.467 Å)
主引用文献Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain.
Science, 375, 2022
7SN0
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Crystal structure of spike protein receptor binding domain of escape mutant SARS-CoV-2 from immunocompromised patient (d146*) in complex with human receptor ACE2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Pan, J, Abraham, J, Clark, S.
登録日2021-10-27
公開日2021-12-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.08 Å)
主引用文献Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain.
Science, 375, 2022
7SN3
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Structure of human SARS-CoV-2 spike glycoprotein trimer bound by neutralizing antibody C1C-A3 Fab (variable region)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Pan, J, Abraham, J, Shankar, S.
登録日2021-10-27
公開日2021-12-08
最終更新日2022-02-02
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain.
Science, 375, 2022
7SN2
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Structure of human SARS-CoV-2 neutralizing antibody C1C-A3 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Pan, J, Abraham, J, Yang, P, Shankar, S.
登録日2021-10-27
公開日2021-12-08
最終更新日2022-02-02
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain.
Science, 375, 2022
6U5O
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Structure of the Human Metapneumovirus Polymerase bound to the phosphoprotein tetramer
分子名称: Phosphoprotein, RNA-directed RNA polymerase L
著者Pan, J, Qian, X, Lattmann, S, Sahili, A.E, Yeo, T.H, Kalocsay, M, Fearns, R, Lescar, J.
登録日2019-08-28
公開日2019-09-25
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structure of the human metapneumovirus polymerase phosphoprotein complex.
Nature, 577, 2020
6ULC
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Structure of full-length, fully glycosylated, non-modified HIV-1 gp160 bound to PG16 Fab at a nominal resolution of 4.6 Angstrom
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Pan, J, Chen, B, Harrison, S.C.
登録日2019-10-07
公開日2020-04-29
最終更新日2020-09-09
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Cryo-EM Structure of Full-length HIV-1 Env Bound With the Fab of Antibody PG16.
J.Mol.Biol., 432, 2020
5KRE
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Covalent inhibitor of LYPLAL1
分子名称: (2~{R})-2-phenylpiperidine-1-carbaldehyde, Lysophospholipase-like protein 1, NITRATE ION
著者Pandit, J.
登録日2016-07-07
公開日2016-07-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism.
Acs Chem.Biol., 11, 2016
6PWU
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Structure of full-length, fully glycosylated, non-modified HIV-1 gp160 bound to PG16 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Pan, J, Chen, B, Harrison, S.C.
登録日2019-07-23
公開日2020-02-26
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (6.2 Å)
主引用文献Cryo-EM Structure of Full-length HIV-1 Env Bound With the Fab of Antibody PG16.
J.Mol.Biol., 432, 2020
2PGG
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BU of 2pgg by Molmil
Crystal Structure of a Birnavirus (IBDV) RNA-dependent RNA Polymerase VP1
分子名称: RNA-directed RNA polymerase
著者Pan, J, Vakharia, V.N, Tao, Y.J.
登録日2007-04-09
公開日2007-05-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The structure of a birnavirus polymerase reveals a distinct active site topology.
Proc.Natl.Acad.Sci.Usa, 104, 2007
4X48
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Crystal structure of GluR2 ligand-binding core
分子名称: GLUTAMIC ACID, Glutamate receptor 2, N-{(3S,4S)-4-[4-(5-cyanothiophen-2-yl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide, ...
著者Pandit, J.
登録日2014-12-02
公開日2015-05-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献The Discovery and Characterization of the alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N-{(3S,4S)-4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242).
J.Med.Chem., 58, 2015
6FCB
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BU of 6fcb by Molmil
Human Methionine Adenosyltransferase II mutant (P115G)
分子名称: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ...
著者Panmanee, J, Antonyuk, S.V, Hasnain, S.S.
登録日2017-12-20
公開日2019-01-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds.
Febs J., 286, 2019
6FBP
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BU of 6fbp by Molmil
Human Methionine Adenosyltransferase II mutant (S114A) in P22121 crystal form
分子名称: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, 1,2-ETHANEDIOL, ACETATE ION, ...
著者Panmanee, J, Antonyuk, S.V, Hasnain, S.S.
登録日2017-12-19
公開日2019-01-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds.
Febs J., 286, 2019
6FBN
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BU of 6fbn by Molmil
Human Methionine Adenosyltransferase II mutant (Q113A)
分子名称: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ...
著者Panmanee, J, Antonyuk, S.V, Hasnain, S.S.
登録日2017-12-19
公開日2019-01-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds.
Febs J., 286, 2019
6FBO
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BU of 6fbo by Molmil
Human Methionine Adenosyltransferase II mutant (S114A) in I222 crystal form
分子名称: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, 1,2-ETHANEDIOL, ADENOSINE, ...
著者Panmanee, J, Antonyuk, S.V, Hasnain, S.S.
登録日2017-12-19
公開日2019-01-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds.
Febs J., 286, 2019
6FCD
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BU of 6fcd by Molmil
Human Methionine Adenosyltransferase II mutant (R264A)
分子名称: 1,2-ETHANEDIOL, ADENOSINE, DI(HYDROXYETHYL)ETHER, ...
著者Panmanee, J, Antonyuk, S.V, Hasnain, S.S.
登録日2017-12-20
公開日2019-01-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds.
Febs J., 286, 2019
7KFV
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BU of 7kfv by Molmil
Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-B12 Fab)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of antibody C1A-B12 Fab, Spike glycoprotein, ...
著者Pan, J, Abraham, J, Clark, L, Clark, S.
登録日2020-10-15
公開日2020-12-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.102 Å)
主引用文献Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2.
Biorxiv, 2020
7KFY
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Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-F10 Fab)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, heavy chain of human antibody C1A-F10 Fab, ...
著者Pan, J, Abraham, J, Clark, L, Clark, S.
登録日2020-10-15
公開日2020-12-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.157 Å)
主引用文献Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2.
Biorxiv, 2020
7KFW
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Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-B3 Fab)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, heavy chain of antibody C1A-B3 Fab, ...
著者Pan, J, Abraham, J, Clark, L, Clark, S.
登録日2020-10-15
公開日2020-12-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.792 Å)
主引用文献Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2.
Biorxiv, 2020
7KFX
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Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-C2 Fab)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, heavy chain of human antibody C1A-C2 Fab, ...
著者Pan, J, Abraham, J, Clark, L, Clark, S.
登録日2020-10-15
公開日2020-12-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.226 Å)
主引用文献Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2.
Biorxiv, 2020
4JIB
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Crystal structure of of PDE2-inhibitor complex
分子名称: 1-(2-hydroxyethyl)-3-(2-methylbutan-2-yl)-5-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8(1H)-one, MAGNESIUM ION, ZINC ION, ...
著者Pandit, J.
登録日2013-03-05
公開日2013-05-01
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, Part I: Transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4LZ5
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BU of 4lz5 by Molmil
Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators
分子名称: GLUTAMIC ACID, Glutamate receptor 2, N-[(2R)-2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide, ...
著者Pandit, J.
登録日2013-07-31
公開日2013-12-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Discovery and Characterization of a Novel Dihydroisoxazole Class of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators.
J.Med.Chem., 56, 2013
4LZ8
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Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators
分子名称: GLUTAMIC ACID, Glutamate receptor 2, N-[(3S)-1-{2-fluoro-4-[(5S)-5-{[(propan-2-ylsulfonyl)amino]methyl}-4,5-dihydro-1,2-oxazol-3-yl]phenyl}pyrrolidin-3-yl]acetamide, ...
著者Pandit, J.
登録日2013-07-31
公開日2013-12-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Discovery and Characterization of a Novel Dihydroisoxazole Class of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators.
J.Med.Chem., 56, 2013
4LZ7
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BU of 4lz7 by Molmil
Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators
分子名称: GLUTAMIC ACID, Glutamate receptor 2, N-({(5S)-3-[3-fluoro-4-(pyrrolidin-1-yl)phenyl]-4,5-dihydro-1,2-oxazol-5-yl}methyl)acetamide, ...
著者Pandit, J.
登録日2013-07-31
公開日2013-12-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Discovery and Characterization of a Novel Dihydroisoxazole Class of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators.
J.Med.Chem., 56, 2013
3Q3B
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6-Amino-4-(pyrimidin-4-yl)pyridones: Novel Glycogen Synthase Kinase-3 Inhibitors
分子名称: 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one, Glycogen synthase kinase-3 beta
著者Pandit, J.
登録日2010-12-21
公開日2011-06-15
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3β inhibitors
Bioorg.Med.Chem.Lett., 21, 2011

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