5KRE

Covalent inhibitor of LYPLAL1

Summary for 5KRE

Entry DOI	10.2210/pdb5kre/pdb
Descriptor	Lysophospholipase-like protein 1, (2~{R})-2-phenylpiperidine-1-carbaldehyde, NITRATE ION, ... (4 entities in total)
Functional Keywords	lyplal1, serine hydrolase, covalent inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Isoform 1: Cytoplasm, cytosol . Isoform 2: Cytoplasm, cytosol : Q5VWZ2
Total number of polymer chains	1
Total formula weight	26772.90
Authors	Pandit, J. (deposition date: 2016-07-07, release date: 2016-07-20, Last modification date: 2023-10-04)
Primary citation	Ahn, K.,Boehm, M.,Brown, M.F.,Calloway, J.,Che, Y.,Chen, J.,Fennell, K.F.,Geoghegan, K.F.,Gilbert, A.M.,Gutierrez, J.A.,Kalgutkar, A.S.,Lanba, A.,Limberakis, C.,Magee, T.V.,O'Doherty, I.,Oliver, R.,Pabst, B.,Pandit, J.,Parris, K.,Pfefferkorn, J.A.,Rolph, T.P.,Patel, R.,Schuff, B.,Shanmugasundaram, V.,Starr, J.T.,Varghese, A.H.,Vera, N.B.,Vernochet, C.,Yan, J. Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism. Acs Chem.Biol., 11:2529-2540, 2016 Cited by PubMed: 27391855 DOI: 10.1021/acschembio.6b00266 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation