5KRE
Covalent inhibitor of LYPLAL1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004622 | molecular_function | lysophospholipase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008150 | biological_process | biological_process |
| A | 0008474 | molecular_function | palmitoyl-(protein) hydrolase activity |
| A | 0016298 | molecular_function | lipase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| A | 0098734 | biological_process | macromolecule depalmitoylation |
| A | 0160049 | biological_process | negative regulation of cGAS/STING signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue 6WG A 301 |
| Chain | Residue |
| A | SER30 |
| A | HOH427 |
| A | TYR66 |
| A | ARG80 |
| A | ILE83 |
| A | SER124 |
| A | MET125 |
| A | LEU181 |
| A | VAL182 |
| A | NO3302 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue NO3 A 302 |
| Chain | Residue |
| A | ARG80 |
| A | SER124 |
| A | MET125 |
| A | CYS128 |
| A | SER148 |
| A | SER149 |
| A | PHE150 |
| A | VAL182 |
| A | 6WG301 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Charge relay system => ECO:0000250|UniProtKB:O75608 |
| Chain | Residue | Details |
| A | SER124 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Charge relay system => ECO:0000305|PubMed:37802025 |
| Chain | Residue | Details |
| A | ASP179 | |
| A | HIS211 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.5, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712 |
| Chain | Residue | Details |
| A | ALA2 |
