3Q3B

6-Amino-4-(pyrimidin-4-yl)pyridones: Novel Glycogen Synthase Kinase-3 Inhibitors

Summary for 3Q3B

• Entry DOI: 10.2210/pdb3q3b/pdb
• Related: 1PYX 1Q3D 1Q41 1Q4L
• Descriptor: Glycogen synthase kinase-3 beta, 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one (3 entities in total)
• Functional Keywords: kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P49841
• Total number of polymer chains: 2
• Total formula weight: 94719.56

Authors

Pandit, J. (deposition date: 2010-12-21, release date: 2011-06-15, Last modification date: 2024-02-21)

Primary citation

Coffman, K.,Brodney, M.,Cook, J.,Lanyon, L.,Pandit, J.,Sakya, S.,Schachter, J.,Tseng-Lovering, E.,Wessel, M.
6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3β inhibitors
Bioorg.Med.Chem.Lett., 21:1429-1433, 2011

PubMed Abstract: The synthesis and structure-activity relationships for a novel series of 6-amino-4-(pyrimidin-4-yl)pyridones derived from a high throughput screening hit are discussed. Optimization of lead matter afforded compounds with good potency, selectivity and central nervous system (CNS) exposure.

PubMed: 21295469
DOI: 10.1016/j.bmcl.2011.01.017

Experimental method

X-RAY DIFFRACTION (2.7 Å)