3Q3B
6-Amino-4-(pyrimidin-4-yl)pyridones: Novel Glycogen Synthase Kinase-3 Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glycogen synthase kinase-3 beta | polymer | 424 | 47081.5 | 2 | UniProt (P49841) Pfam (PF00069) | Homo sapiens (human) | GSK-3 beta |
| 2 | C, D (A, B) | 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one | non-polymer | 278.3 | 2 | Chemie (55E) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 420 (UniProt: P49841)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 94162.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 556.6 | |
| All* | Total formula weight | 94719.6 |
