7SN3

Structure of human SARS-CoV-2 spike glycoprotein trimer bound by neutralizing antibody C1C-A3 Fab (variable region)

Summary for 7SN3

• Entry DOI: 10.2210/pdb7sn3/pdb
• Related: 7SN2
• EMDB information: 25209 25210
• Descriptor: Spike glycoprotein, neutralizing antibody C1C-A3 heavy chain variable region, neutralizing antibody C1C-A3 light chain variable region, ... (5 entities in total)
• Functional Keywords: covid-19, sars-cov-2, neutralizing antibody, neutralization escape, immune system, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 9
• Total formula weight: 594046.74

Authors

Pan, J.,Abraham, J.,Shankar, S. (deposition date: 2021-10-27, release date: 2021-12-08, Last modification date: 2022-02-02)

• Primary citation: Nabel, K.G.,Clark, S.A.,Shankar, S.,Pan, J.,Clark, L.E.,Yang, P.,Coscia, A.,McKay, L.G.A.,Varnum, H.H.,Brusic, V.,Tolan, N.V.,Zhou, G.,Desjardins, M.,Turbett, S.E.,Kanjilal, S.,Sherman, A.C.,Dighe, A.,LaRocque, R.C.,Ryan, E.T.,Tylek, C.,Cohen-Solal, J.F.,Darcy, A.T.,Tavella, D.,Clabbers, A.,Fan, Y.,Griffiths, A.,Correia, I.R.,Seagal, J.,Baden, L.R.,Charles, R.C.,Abraham, J.; Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain.; Science, 375:eabl6251-eabl6251, 2022; PubMed: 34855508; DOI: 10.1126/science.abl6251

Experimental method

ELECTRON MICROSCOPY (3.1 Å)