4X48

Crystal structure of GluR2 ligand-binding core

Summary for 4X48

• Entry DOI: 10.2210/pdb4x48/pdb
• Related: 4LZ5 4LZ7 4LZ8
• Descriptor: Glutamate receptor 2, GLUTAMIC ACID, ZINC ION, ... (5 entities in total)
• Functional Keywords: ampa receptor, allosteric modulator, membrane protein
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P19491
• Total number of polymer chains: 3
• Total formula weight: 92584.94

Authors

Pandit, J. (deposition date: 2014-12-02, release date: 2015-05-06, Last modification date: 2023-09-27)

• Primary citation: Shaffer, C.L.,Patel, N.C.,Schwarz, J.,Scialis, R.J.,Wei, Y.,Hou, X.J.,Xie, L.,Karki, K.,Bryce, D.K.,Osgood, S.M.,Hoffmann, W.E.,Lazzaro, J.T.,Chang, C.,McGinnis, D.F.,Lotarski, S.M.,Liu, J.,Obach, R.S.,Weber, M.L.,Chen, L.,Zasadny, K.R.,Seymour, P.A.,Schmidt, C.J.,Hajos, M.,Hurst, R.S.,Pandit, J.,O'Donnell, C.J.; The Discovery and Characterization of the alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N-{(3S,4S)-4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242).; J.Med.Chem., 58:4291-4308, 2015; PubMed: 25905800; DOI: 10.1021/acs.jmedchem.5b00300

Experimental method

X-RAY DIFFRACTION (1.89 Å)