4X48

Crystal structure of GluR2 ligand-binding core

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Glutamate receptor 2	polymer	275	30343.8	3	UniProt (P19491) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	A, B, C	GLUTAMIC ACID	non-polymer		147.1	3	Chemie (GLU)
3	A, B, C	ZINC ION	non-polymer		65.4	5	Chemie (ZN)
4	B, C	N-{(3S,4S)-4-[4-(5-cyanothiophen-2-yl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide	non-polymer		392.5	2	Chemie (XPF)
5		water	water		18.0	702	Chemie (HOH)

Sequence modifications

A, B, C: 392 - 506 (UniProt: P19491)

PDB	External Database	Details
Gly 378	-	expression tag
Ser 379	-	expression tag
Ala 380	-	expression tag
Met 381	-	expression tag
Gly 382	-	expression tag
Ser 383	-	expression tag
Gly 384	-	expression tag
Asn 385	-	expression tag
Asp 386	-	expression tag
Thr 387	-	expression tag
Ser 388	-	expression tag
Arg 389	-	expression tag
Gly 390	-	expression tag
Ala 391	-	expression tag

A, B, C: 632 - 775 (UniProt: P19491)

PDB	External Database	Details
Gly 507	-	linker
Thr 508	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	91031.5
Non-Polymers*	Number of molecules	10
	Total formula weight	1553.4
All*	Total formula weight	92584.9

*Water molecules are not included.