7SN0

Crystal structure of spike protein receptor binding domain of escape mutant SARS-CoV-2 from immunocompromised patient (d146*) in complex with human receptor ACE2

Summary for 7SN0

• Entry DOI: 10.2210/pdb7sn0/pdb
• Descriptor: Angiotensin-converting enzyme 2, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)]alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (13 entities in total)
• Functional Keywords: covid-19, sars-cov-2, spike protein, neutralization escape mutant, ace2, receptor binding, viral protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 217113.63

Authors

Pan, J.,Abraham, J.,Clark, S. (deposition date: 2021-10-27, release date: 2021-12-08, Last modification date: 2023-10-18)

• Primary citation: Nabel, K.G.,Clark, S.A.,Shankar, S.,Pan, J.,Clark, L.E.,Yang, P.,Coscia, A.,McKay, L.G.A.,Varnum, H.H.,Brusic, V.,Tolan, N.V.,Zhou, G.,Desjardins, M.,Turbett, S.E.,Kanjilal, S.,Sherman, A.C.,Dighe, A.,LaRocque, R.C.,Ryan, E.T.,Tylek, C.,Cohen-Solal, J.F.,Darcy, A.T.,Tavella, D.,Clabbers, A.,Fan, Y.,Griffiths, A.,Correia, I.R.,Seagal, J.,Baden, L.R.,Charles, R.C.,Abraham, J.; Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain.; Science, 375:eabl6251-eabl6251, 2022; PubMed: 34855508; DOI: 10.1126/science.abl6251

Experimental method

X-RAY DIFFRACTION (3.08 Å)