7SN0
Crystal structure of spike protein receptor binding domain of escape mutant SARS-CoV-2 from immunocompromised patient (d146*) in complex with human receptor ACE2
Summary for 7SN0
Entry DOI | 10.2210/pdb7sn0/pdb |
Descriptor | Angiotensin-converting enzyme 2, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)]alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (13 entities in total) |
Functional Keywords | covid-19, sars-cov-2, spike protein, neutralization escape mutant, ace2, receptor binding, viral protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 217113.63 |
Authors | Pan, J.,Abraham, J.,Clark, S. (deposition date: 2021-10-27, release date: 2021-12-08, Last modification date: 2023-10-18) |
Primary citation | Nabel, K.G.,Clark, S.A.,Shankar, S.,Pan, J.,Clark, L.E.,Yang, P.,Coscia, A.,McKay, L.G.A.,Varnum, H.H.,Brusic, V.,Tolan, N.V.,Zhou, G.,Desjardins, M.,Turbett, S.E.,Kanjilal, S.,Sherman, A.C.,Dighe, A.,LaRocque, R.C.,Ryan, E.T.,Tylek, C.,Cohen-Solal, J.F.,Darcy, A.T.,Tavella, D.,Clabbers, A.,Fan, Y.,Griffiths, A.,Correia, I.R.,Seagal, J.,Baden, L.R.,Charles, R.C.,Abraham, J. Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain. Science, 375:eabl6251-eabl6251, 2022 Cited by PubMed: 34855508DOI: 10.1126/science.abl6251 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.08 Å) |
Structure validation
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