4WYM
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![BU of 4wym by Molmil](/molmil-images/mine/4wym) | Structural basis of HIV-1 capsid recognition by CPSF6 | Descriptor: | Capsid protein p24, ISOFORM 2 OF CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 6 | Authors: | Battacharya, A, Taylor, A.B, Hart, P.J, Ivanov, D.N. | Deposit date: | 2014-11-17 | Release date: | 2014-12-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of HIV-1 capsid recognition by PF74 and CPSF6. Proc.Natl.Acad.Sci.USA, 111, 2014
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7Z3F
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![BU of 7z3f by Molmil](/molmil-images/mine/7z3f) | Crystal structure of the cupredoxin AcoP from Acidithiobacillus ferrooxidans, oxidized form | Descriptor: | ACETATE ION, AcoP, CHLORIDE ION, ... | Authors: | Leone, P, Sciara, G, Ilbert, M. | Deposit date: | 2022-03-02 | Release date: | 2023-09-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Beyond the coupled distortion model: structural analysis of the single domain cupredoxin AcoP, a green mononuclear copper centre with original features. Dalton Trans, 53, 2024
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4WZN
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![BU of 4wzn by Molmil](/molmil-images/mine/4wzn) | CRYSTAL STRUCTURE OF THE 2B PROTEIN SOLUBLE DOMAIN FROM HEPATITIS A VIRUS | Descriptor: | GLYCEROL, Genome polyprotein | Authors: | Garriga, D, Vives-Adrian, L, Buxaderas, M, Ferreira-da-Silva, F, Almeida, B, Macedo-Ribeiro, S, Pereira, P.J, Verdaguer, N. | Deposit date: | 2014-11-20 | Release date: | 2015-01-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Basis for Host Membrane Remodeling Induced by Protein 2B of Hepatitis A Virus. J.Virol., 89, 2015
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5LVQ
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![BU of 5lvq by Molmil](/molmil-images/mine/5lvq) | Crystal structure of human PCAF bromodomain in complex with compound-D (CPD-D), N-methyl-2-(tetrahydro-2H-pyran-4-yloxy)benzamide | Descriptor: | 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Histone acetyltransferase KAT2B, ... | Authors: | Chaikuad, A, Filippakopoulos, P, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Hopkins, A.L, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2016-09-14 | Release date: | 2016-10-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening. ACS Med Chem Lett, 7, 2016
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6EEI
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![BU of 6eei by Molmil](/molmil-images/mine/6eei) | Crystal structure of Arabidopsis thaliana phenylacetaldehyde synthase in complex with L-phenylalanine | Descriptor: | PHENYLALANINE, SULFATE ION, Tyrosine decarboxylase 1 | Authors: | Torrens-Spence, M.P, Chiang, Y, Smith, T, Vicent, M.A, Wang, Y, Weng, J.K. | Deposit date: | 2018-08-14 | Release date: | 2018-09-19 | Last modified: | 2020-06-03 | Method: | X-RAY DIFFRACTION (1.99001348 Å) | Cite: | Structural basis for divergent and convergent evolution of catalytic machineries in plant aromatic amino acid decarboxylase proteins. Proc.Natl.Acad.Sci.USA, 117, 2020
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4HQJ
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![BU of 4hqj by Molmil](/molmil-images/mine/4hqj) | Crystal structure of Na+,K+-ATPase in the Na+-bound state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHOLESTEROL, MAGNESIUM ION, ... | Authors: | Nyblom, M, Reinhard, L, Gourdon, P, Nissen, P. | Deposit date: | 2012-10-25 | Release date: | 2013-10-02 | Last modified: | 2014-09-10 | Method: | X-RAY DIFFRACTION (4.3 Å) | Cite: | Crystal structure of Na+, K(+)-ATPase in the Na(+)-bound state. Science, 342, 2013
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4X3I
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![BU of 4x3i by Molmil](/molmil-images/mine/4x3i) | The crystal structure of Arc N-lobe complexed with CAMK2A fragment | Descriptor: | Activity-regulated cytoskeleton-associated protein, CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA | Authors: | Zhang, W, Ward, M, Leahy, D, Worley, P. | Deposit date: | 2014-11-30 | Release date: | 2015-06-03 | Last modified: | 2017-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron, 86, 2015
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5LLM
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![BU of 5llm by Molmil](/molmil-images/mine/5llm) | Structure of the thermostabilized EAAT1 cryst mutant in complex with L-ASP and the allosteric inhibitor UCPH101 | Descriptor: | 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile, ASPARTIC ACID, Excitatory amino acid transporter 1,Neutral amino acid transporter B(0),Excitatory amino acid transporter 1, ... | Authors: | Canul-Tec, J, Assal, R, Legrand, P, Reyes, N. | Deposit date: | 2016-07-27 | Release date: | 2017-04-19 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Structure and allosteric inhibition of excitatory amino acid transporter 1. Nature, 544, 2017
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4LVA
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![BU of 4lva by Molmil](/molmil-images/mine/4lva) | Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | 1,2-ETHANEDIOL, N-(4-{[4-(pyrrolidin-1-yl)piperidin-1-yl]sulfonyl}benzyl)-2H-pyrido[4,3-e][1,2,4]thiadiazin-3-amine 1,1-dioxide, Nicotinamide phosphoribosyltransferase, ... | Authors: | Giannetti, A.M, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y, Hua, R, Wang, C, Zhao, Q, Liederer, B.M, Liu, Y, O'Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhao, G, Dragovich, P.S. | Deposit date: | 2013-07-26 | Release date: | 2013-09-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
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2UZL
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![BU of 2uzl by Molmil](/molmil-images/mine/2uzl) | Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor | Descriptor: | 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 | Authors: | Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. | Deposit date: | 2007-04-30 | Release date: | 2007-06-26 | Last modified: | 2019-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping. Bioorg.Med.Chem.Lett., 17, 2007
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6AW8
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![BU of 6aw8 by Molmil](/molmil-images/mine/6aw8) | 2.25A resolution domain swapped dimer structure of SAH bound catechol O-methyltransferase (COMT) from Nannospalax galili | Descriptor: | CALCIUM ION, Catechol O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Lovell, S, Mehzabeen, N, Battaile, K.P, Deng, Y, Hanzlik, R.P, Shams, I, Moskovitz, J. | Deposit date: | 2017-09-05 | Release date: | 2018-09-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Crystal structure of the catechol-o-methyl transferase (COMT) enzyme of the subterranean mole rat (Spalax) and the effect of L136M substitution To be published
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4XBU
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![BU of 4xbu by Molmil](/molmil-images/mine/4xbu) | In vitro Crystal Structure of PAK4 in complex with Inka peptide | Descriptor: | Protein FAM212A, Serine/threonine-protein kinase PAK 4 | Authors: | Baskaran, Y, Ang, K.C, Anekal, P.V, Chan, W.L, Grimes, J.M, Manser, E, Robinson, R.C. | Deposit date: | 2014-12-17 | Release date: | 2015-12-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1 Nat Commun, 6, 2015
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5TIW
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![BU of 5tiw by Molmil](/molmil-images/mine/5tiw) | |
7EC0
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![BU of 7ec0 by Molmil](/molmil-images/mine/7ec0) | Crystal structure of juvenile hormone acid methyltransferase JHAMT in complex with S-Adenosyl homocysteine and methyl farnesoate | Descriptor: | Juvenile hormone acid methyltransferase, Methyl farnesoate, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Guo, P.C, Zhang, Y.S, Zhang, L, Xu, H.Y, Xia, Q.Y. | Deposit date: | 2021-03-11 | Release date: | 2021-09-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.494 Å) | Cite: | Structural basis for juvenile hormone biosynthesis by the juvenile hormone acid methyltransferase. J.Biol.Chem., 297, 2021
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3IYV
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![BU of 3iyv by Molmil](/molmil-images/mine/3iyv) | Clathrin D6 coat as full-length Triskelions | Descriptor: | Clathrin heavy chain, Clathrin light chain A | Authors: | Johnson, G.T, Fotin, A, Cheng, Y, Sliz, P, Grigorieff, N, Harrison, S.C, Kirchhausen, T, Walz, T. | Deposit date: | 2010-06-17 | Release date: | 2010-07-21 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (7.9 Å) | Cite: | Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature, 432, 2004
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2JC9
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![BU of 2jc9 by Molmil](/molmil-images/mine/2jc9) | Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with adenosine | Descriptor: | ADENOSINE, CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, ... | Authors: | Wallden, K, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg, S.L, Hogbom, M, Karlberg, T, Kotenyova, T, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Loppnau, P, Weigelt, J, Welin, M, Nordlund, P. | Deposit date: | 2006-12-21 | Release date: | 2007-01-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal Structure of Human Cytosolic 5'-Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition J.Biol.Chem., 282, 2007
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5LSO
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![BU of 5lso by Molmil](/molmil-images/mine/5lso) | |
3IA3
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![BU of 3ia3 by Molmil](/molmil-images/mine/3ia3) | |
5M1W
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![BU of 5m1w by Molmil](/molmil-images/mine/5m1w) | Structure of a stable G-hairpin | Descriptor: | DNA (5'-D(*GP*TP*GP*TP*GP*GP*GP*TP*GP*TP*G)-3') | Authors: | Gajarsky, M, Zivkovic, M.L, Stadlbauer, P, Pagano, B, Fiala, R, Amato, J, Tomaska, L, Sponer, J, Plavec, J, Trantirek, L. | Deposit date: | 2016-10-11 | Release date: | 2017-03-01 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure of a Stable G-Hairpin. J. Am. Chem. Soc., 139, 2017
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7ZOZ
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![BU of 7zoz by Molmil](/molmil-images/mine/7zoz) | Crystal structure of Siglec-15 in complex with Fab | Descriptor: | Anti-Siglec 15 Fab HC, Anti-Siglec 15 Fab LC, Sialic acid-binding Ig-like lectin 15 | Authors: | Lenza, M.P, Oyenarte, I, Jimenez-Barbero, J, Ereno-Orbea, J. | Deposit date: | 2022-04-26 | Release date: | 2023-06-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.104 Å) | Cite: | Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b. Nat Commun, 14, 2023
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5FFY
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![BU of 5ffy by Molmil](/molmil-images/mine/5ffy) | Crystal structure of the bromodomain of human BRPF1 in complex with a benzimidazole ligand | Descriptor: | 4-ethyl-~{N}-(6-methoxy-1,3-dimethyl-2-oxidanylidene-benzimidazol-5-yl)benzenesulfonamide, Peregrin | Authors: | Tallant, C, Savitsky, P, Nunez-Alonso, G, Kopec, J, Fedorov, O, Filippakopoulos, P, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S. | Deposit date: | 2015-12-19 | Release date: | 2015-12-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal structure of the bromodomain of human BRPF1 in complex with a benzimidazole ligand To Be Published
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7ZOR
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![BU of 7zor by Molmil](/molmil-images/mine/7zor) | Crystal structure of anti-Siglec-15 Fab | Descriptor: | Anti-siglec15 FAB HC, Anti-siglec15 FAB LC | Authors: | Lenza, M.P, Oyenarte, I, Jimenez-Barbero, J, Ereno-Orbea, J. | Deposit date: | 2022-04-26 | Release date: | 2023-06-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.933 Å) | Cite: | Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b. Nat Commun, 14, 2023
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5FG4
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![BU of 5fg4 by Molmil](/molmil-images/mine/5fg4) | Crystal structure of the bromodomain of human BRPF1 in complex with OF-1 chemical probe | Descriptor: | 4-bromanyl-~{N}-(6-methoxy-1,3-dimethyl-2-oxidanylidene-benzimidazol-5-yl)-2-methyl-benzenesulfonamide, Peregrin | Authors: | Tallant, C, Owen, D.R, Gerstenberger, B.S, Savitsky, P, Chaikuad, A, Fedorov, O, Nunez-Alonso, G, Filippakopoulos, P, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Muller, S, Knapp, S. | Deposit date: | 2015-12-20 | Release date: | 2016-01-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal structure of the bromodomain of human BRPF1 in complex with OF-1 chemical probe To Be Published
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4KWH
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![BU of 4kwh by Molmil](/molmil-images/mine/4kwh) | The crystal structure of angucycline C-6 ketoreductase LanV with bound NADP | Descriptor: | ACETIC ACID, DI(HYDROXYETHYL)ETHER, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Paananen, P, Patrikainen, P, Kallio, P, Mantsala, P, Niemi, J, Niiranen, L, Metsa-Ketela, M. | Deposit date: | 2013-05-24 | Release date: | 2013-07-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis. Biochemistry, 52, 2013
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3W36
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![BU of 3w36 by Molmil](/molmil-images/mine/3w36) | Crystal structure of holo-type bacterial Vanadium-dependent chloroperoxidase | Descriptor: | NapH1, VANADATE ION | Authors: | Liscombe, D.K, Miyanaga, A, Fielding, E, Bernhardt, P, Li, A, Winter, J.M, Gilson, M.K, Noel, J.P, Moore, B.S. | Deposit date: | 2012-12-11 | Release date: | 2013-12-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis. Biochemistry, 2022
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