5LVQ
Crystal structure of human PCAF bromodomain in complex with compound-D (CPD-D), N-methyl-2-(tetrahydro-2H-pyran-4-yloxy)benzamide
Summary for 5LVQ
Entry DOI | 10.2210/pdb5lvq/pdb |
Descriptor | Histone acetyltransferase KAT2B, 1,2-ETHANEDIOL, N-methyl-2-(tetrahydro-2H-pyran-4-yloxy)benzamide, ... (5 entities in total) |
Functional Keywords | signaling protein, bromodomain, histone acetyltransferase kat2b, histone, acetylation, acetyllysine, epigenetics, structural genomics consortium (sgc), transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q92831 |
Total number of polymer chains | 2 |
Total formula weight | 28968.49 |
Authors | Chaikuad, A.,Filippakopoulos, P.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Hopkins, A.L.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2016-09-14, release date: 2016-10-26, Last modification date: 2024-05-08) |
Primary citation | Navratilova, I.,Aristotelous, T.,Picaud, S.,Chaikuad, A.,Knapp, S.,Filappakopoulos, P.,Hopkins, A.L. Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening. ACS Med Chem Lett, 7:1213-1218, 2016 Cited by PubMed: 27994766DOI: 10.1021/acsmedchemlett.6b00154 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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