5LVQ
Crystal structure of human PCAF bromodomain in complex with compound-D (CPD-D), N-methyl-2-(tetrahydro-2H-pyran-4-yloxy)benzamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone acetyltransferase KAT2B | polymer | 119 | 14172.4 | 2 | UniProt (Q92831) Pfam (PF00439) | Homo sapiens (Human) | Histone acetyltransferase PCAF,Histone acetylase PCAF,Lysine acetyltransferase 2B,P300/CBP-associated factor,P/CAF |
| 2 | C, D, E, G, H (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 3 | F (A) | N-methyl-2-(tetrahydro-2H-pyran-4-yloxy)benzamide | non-polymer | 235.3 | 1 | Chemie (2LX) | |||
| 4 | I (B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 127 | Chemie (HOH) |
Sequence modifications
A, B: 715 - 831 (UniProt: Q92831)
| PDB | External Database | Details |
|---|---|---|
| Ser 713 | - | expression tag |
| Met 714 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28344.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 623.8 | |
| All* | Total formula weight | 28968.5 |
