5FG4

Crystal structure of the bromodomain of human BRPF1 in complex with OF-1 chemical probe

Summary for 5FG4

DescriptorPeregrin, 4-bromanyl-~{N}-(6-methoxy-1,3-dimethyl-2-oxidanylidene-benzimidazol-5-yl)-2-methyl-benzenesulfonamide (3 entities in total)
Functional Keywordsperegrin, moz-morf complex, transcription
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  P55201
Total number of polymer chains1
Total molecular weight14144.01
Authors
Primary citation
Tallant, C.,Owen, D.R.,Gerstenberger, B.S.,Savitsky, P.,Chaikuad, A.,Fedorov, O.,Nunez-Alonso, G.,Filippakopoulos, P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Muller, S.,Knapp, S.
Crystal structure of the bromodomain of human BRPF1 in complex with OF-1 chemical probe
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.65 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2504005.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution