7ZOZ

Crystal structure of Siglec-15 in complex with Fab

Summary for 7ZOZ

Entry DOI	10.2210/pdb7zoz/pdb
Descriptor	Sialic acid-binding Ig-like lectin 15, Anti-Siglec 15 Fab HC, Anti-Siglec 15 Fab LC, ... (4 entities in total)
Functional Keywords	sialic acid, siglec, immune system, cancer
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	81742.60
Authors	Lenza, M.P.,Oyenarte, I.,Jimenez-Barbero, J.,Ereno-Orbea, J. (deposition date: 2022-04-26, release date: 2023-06-28, Last modification date: 2024-02-07)
Primary citation	Lenza, M.P.,Egia-Mendikute, L.,Antonana-Vildosola, A.,Soares, C.O.,Coelho, H.,Corzana, F.,Bosch, A.,Manisha, P.,Quintana, J.I.,Oyenarte, I.,Unione, L.,Moure, M.J.,Azkargorta, M.,Atxabal, U.,Sobczak, K.,Elortza, F.,Sutherland, J.D.,Barrio, R.,Marcelo, F.,Jimenez-Barbero, J.,Palazon, A.,Ereno-Orbea, J. Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b. Nat Commun, 14:3496-3496, 2023 Cited by PubMed: 37311743 DOI: 10.1038/s41467-023-39119-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.104 Å)

Structure validation