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PDB: 472 results
8C0L
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BU of 8c0l by Molmil
FC-THF stabilizer of 14-3-3 and ERalpha
Descriptor: 14-3-3 protein sigma, ERalpha peptide, Fusicoccin A-THF
Authors:Visser, E.J, Ottmann, C.
Deposit date:2022-12-17
Release date:2024-07-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer
To Be Published
4J24
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BU of 4j24 by Molmil
Estrogen Receptor in complex with proline-flanked LXXLL peptides
Descriptor: 19-mer peptide, ESTRADIOL, Estrogen receptor beta
Authors:Fuchs, S, Nguyen, H.D, Phan, T, Burton, M, Nieto, L, de Vries-van Leeuwen, I, Schmidt, A, Goodarzifard, M, Agten, S, Rose, R, Ottmann, C, Milroy, L.G, Brunsveld, L.
Deposit date:2013-02-04
Release date:2013-03-13
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Proline primed helix length as a modulator of the nuclear receptor-coactivator interaction
J.Am.Chem.Soc., 135, 2013
6F09
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BU of 6f09 by Molmil
Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide
Descriptor: 14-3-3 protein zeta/delta, Ubiquitin carboxyl-terminal hydrolase 8
Authors:Centorrino, F, Ballone, A, Ottmann, C, Guo, S, Leysen, S.
Deposit date:2017-11-17
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.594 Å)
Cite:Biophysical and structural insight into the USP8/14-3-3 interaction.
FEBS Lett., 592, 2018
5EXA
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BU of 5exa by Molmil
Small-molecule stabilization of the 14-3-3/Gab2 PPI interface
Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, Fusicoccin A-THF derivative, ...
Authors:Bier, D, Ottmann, C.
Deposit date:2015-11-23
Release date:2016-05-04
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface.
Chemmedchem, 11, 2016
6F08
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BU of 6f08 by Molmil
14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1)
Descriptor: 14-3-3 protein zeta/delta, PENTAETHYLENE GLYCOL, Son of sevenless homolog 1
Authors:Ballone, A, Centorrino, F, Ottmann, C, Guo, S, Leysen, S.
Deposit date:2017-11-17
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural characterization of 14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1).
J. Struct. Biol., 202, 2018
5EWZ
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BU of 5ewz by Molmil
Small-molecule stabilization of the 14-3-3/Gab2 PPI interface
Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, GRB2-associated-binding protein 2
Authors:Bier, D, Ottmann, C.
Deposit date:2015-11-23
Release date:2016-05-04
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface.
Chemmedchem, 11, 2016
5EC9
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BU of 5ec9 by Molmil
Retinoic acid receptor alpha in complex with chiral dihydrobenzofuran benzoic acid 9a and a fragment of the coactivator TIF2
Descriptor: 4-[(11S,15R)-4,4,7,7-Tetramethyl-16-oxatetracyclo[8.6.0.03,8.011,15]hexadeca-1(10),2,8-trien-11-yl]benzoic acid, LYS-HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP, Retinoic acid receptor RXR-alpha
Authors:Leysen, S, Ottmann, C, Schafer, A, Scheepstra, M, Brunsveld, L, Sunden, R, Ma, J.N, Burnstein, E.S, Olsson, R.
Deposit date:2015-10-20
Release date:2016-03-09
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation.
J.Med.Chem., 59, 2016
4J26
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BU of 4j26 by Molmil
Estrogen Receptor in complex with proline-flanked LXXLL peptides
Descriptor: 12-mer Peptide, ESTRADIOL, Estrogen receptor beta
Authors:Fuchs, S, Nguyen, H.D, Phan, T, Burton, M, Nieto, L, de Vries-van Leeuwen, I, Schmidt, A, Goodarzifard, M, Agten, S, Rose, R, Ottmann, C, Milroy, L.G, Brunsveld, L.
Deposit date:2013-02-04
Release date:2013-03-13
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Proline primed helix length as a modulator of the nuclear receptor-coactivator interaction
J.Am.Chem.Soc., 135, 2013
7OR5
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BU of 7or5 by Molmil
Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ162
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Neurogenic locus notch homolog protein 4, ...
Authors:Centorrino, F, Wu, Q, Ottmann, C.
Deposit date:2021-06-04
Release date:2022-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OR7
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BU of 7or7 by Molmil
Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ178
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Centorrino, F, Wu, Q, Ottmann, C.
Deposit date:2021-06-04
Release date:2022-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OQ9
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BU of 7oq9 by Molmil
Ternary complex of 14-3-3 sigma, Pin1pS72 phosphopeptide, and WQ136
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ...
Authors:Centorrino, F, Ottmann, C.
Deposit date:2021-06-02
Release date:2022-08-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OQA
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BU of 7oqa by Molmil
Ternary complex of 14-3-3 sigma, Pin1pS72 phosphopeptide, and WQ162
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ...
Authors:Centorrino, F, Ottmann, C.
Deposit date:2021-06-02
Release date:2022-08-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
4DAT
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BU of 4dat by Molmil
Structure of 14-3-3 sigma in complex with PADI6 14-3-3 binding motif II
Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, Peptidylarginine Deiminase type VI
Authors:Rose, R, Rose, M, Ottmann, C.
Deposit date:2012-01-13
Release date:2012-06-13
Last modified:2012-10-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI.
J.Struct.Biol., 180, 2012
4DHS
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BU of 4dhs by Molmil
Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
Descriptor: (2-{2-[(3,5-dichlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 PROTEIN SIGMA, CHLORIDE ION, ...
Authors:Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C.
Deposit date:2012-01-30
Release date:2013-07-31
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
Chem.Commun.(Camb.), 49, 2013
3I74
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BU of 3i74 by Molmil
Crystal Structure of the plant subtilisin-like protease SBT3 in complex with a chloromethylketone inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACE-PHE-GLU-LYS-ALA chloromethylketone INHIBITOR, Subtilisin-like protease, ...
Authors:Rose, R, Ottmann, C.
Deposit date:2009-07-08
Release date:2010-01-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3.
Proc.Natl.Acad.Sci.USA, 106, 2009
5MK4
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BU of 5mk4 by Molmil
Crystal structure of the Retinoid X Receptor alpha in complex with synthetic honokiol derivative 7 and a fragment of the TIF2 co-activator.
Descriptor: (~{E})-3-[3-(2-methyl-5-phenyl-phenyl)-4-oxidanyl-phenyl]prop-2-enoic acid, CHLORIDE ION, Nuclear receptor coactivator 2, ...
Authors:Andrei, S.A, Scheepstra, M, Brunsveld, L, Ottmann, C.
Deposit date:2016-12-02
Release date:2017-11-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
ACS Chem Neurosci, 8, 2017
6GHP
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BU of 6ghp by Molmil
14-3-3sigma in complex with a TASK3 peptide stabilized by semi-synthetic natural product FC-NAc
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Potassium channel subfamily K member 9, ...
Authors:Andrei, S.A, de Vink, P.J, Brunsveld, L, Ottmann, C, Higuchi, Y.
Deposit date:2018-05-08
Release date:2018-08-01
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14-3-3 Protein-Protein Interactions.
Angew. Chem. Int. Ed. Engl., 57, 2018
6HEP
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BU of 6hep by Molmil
Crystal structure of human 14-3-3 beta in complex with CFTR R-domain peptide pS753-pS768
Descriptor: 14-3-3 protein beta/alpha, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Cystic fibrosis transmembrane conductance regulator
Authors:Stevers, L.M, Ottmann, C, Brunsveld, L.
Deposit date:2018-08-20
Release date:2018-10-24
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:A Thermodynamic Model for Multivalency in 14-3-3 Protein-Protein Interactions.
J. Am. Chem. Soc., 140, 2018
6G8K
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BU of 6g8k by Molmil
14-3-3sigma in complex with a S131beta3S mutated YAP pS127 phosphopeptide
Descriptor: 14-3-3 protein sigma, ACE-ARG-ALA-HIS-SEP-SER-PRO-ALA-BSE-LEU-GLN, CHLORIDE ION, ...
Authors:Andrei, S.A, Thijssen, V, Brunsveld, L, Ottmann, C, Milroy, L.G.
Deposit date:2018-04-09
Release date:2019-04-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:A study on the effect of synthetic alpha-to-beta3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins.
Chem.Commun.(Camb.), 55, 2019
5MHC
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BU of 5mhc by Molmil
Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide
Descriptor: 14-3-3 protein sigma, CALCIUM ION, LYS-LEU-MET-PHE-LYS-TPO-GLU-GLY-PRO-ASP-SER-ASP, ...
Authors:Andrei, S, Ottmann, C, Leysen, S.
Deposit date:2016-11-24
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.
FEBS Lett., 591, 2017
5MOC
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BU of 5moc by Molmil
Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Andrei, S, Ottmann, C, Leysen, S.
Deposit date:2016-12-14
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.
FEBS Lett., 591, 2017
5MXO
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BU of 5mxo by Molmil
Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide stabilized by Fusicoccin-A
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ...
Authors:Andrei, S, Ottmann, C, Leysen, S.
Deposit date:2017-01-24
Release date:2017-11-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.
FEBS Lett., 591, 2017
6G8P
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BU of 6g8p by Molmil
14-3-3sigma in complex with a P129beta3P and L132beta3L mutated YAP pS127 phosphopeptide
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
Authors:Andrei, S.A, Thijssen, V, Brunsveld, L, Ottmann, C, Milroy, L.G.
Deposit date:2018-04-09
Release date:2019-04-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A study on the effect of synthetic alpha-to-beta3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins.
Chem.Commun.(Camb.), 55, 2019
6G8L
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BU of 6g8l by Molmil
14-3-3sigma in complex with a L132beta3L mutated YAP pS127 phosphopeptide
Descriptor: 14-3-3 protein sigma, ACE-ARG-ALA-HIS-SEP-SER-PRO-ALA-SER-BLE-GLN, CHLORIDE ION, ...
Authors:Andrei, S.A, Thijssen, V, Brunsveld, L, Ottmann, C, Milroy, L.G.
Deposit date:2018-04-09
Release date:2019-04-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:A study on the effect of synthetic alpha-to-beta3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins.
Chem.Commun.(Camb.), 55, 2019
3P1S
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BU of 3p1s by Molmil
Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 peptide and stabilizer fusicoccin A
Descriptor: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CHLORIDE ION, ...
Authors:Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C.
Deposit date:2010-09-30
Release date:2011-10-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface
Chem. Biol., 20, 2013

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