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5MK4

Crystal structure of the Retinoid X Receptor alpha in complex with synthetic honokiol derivative 7 and a fragment of the TIF2 co-activator.

Summary for 5MK4
Entry DOI10.2210/pdb5mk4/pdb
DescriptorRetinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, (~{E})-3-[3-(2-methyl-5-phenyl-phenyl)-4-oxidanyl-phenyl]prop-2-enoic acid, ... (5 entities in total)
Functional Keywordsrxr tif2 honokiol, transcription
Biological sourceHomo sapiens (Human)
More
Cellular locationNucleus : P19793 Q15596
Total number of polymer chains4
Total formula weight54884.67
Authors
Andrei, S.A.,Scheepstra, M.,Brunsveld, L.,Ottmann, C. (deposition date: 2016-12-02, release date: 2017-11-08, Last modification date: 2024-01-17)
Primary citationScheepstra, M.,Andrei, S.A.,de Vries, R.M.J.M.,Meijer, F.A.,Ma, J.N.,Burstein, E.S.,Olsson, R.,Ottmann, C.,Milroy, L.G.,Brunsveld, L.
Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
ACS Chem Neurosci, 8:2065-2077, 2017
Cited by
PubMed: 28691794
DOI: 10.1021/acschemneuro.7b00216
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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