5MK4
Crystal structure of the Retinoid X Receptor alpha in complex with synthetic honokiol derivative 7 and a fragment of the TIF2 co-activator.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Retinoic acid receptor RXR-alpha | polymer | 229 | 25670.8 | 2 | UniProt (P19793) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha |
| 2 | B, D (B, D) | Nuclear receptor coactivator 2 | polymer | 11 | 1405.7 | 2 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | E, G (A, C) | (~{E})-3-[3-(2-methyl-5-phenyl-phenyl)-4-oxidanyl-phenyl]prop-2-enoic acid | non-polymer | 330.4 | 2 | Chemie (I5W) | |||
| 4 | F, H (A, C) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 476 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 54153.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 731.7 | |
| All* | Total formula weight | 54884.7 |
