5MK4
Crystal structure of the Retinoid X Receptor alpha in complex with synthetic honokiol derivative 7 and a fragment of the TIF2 co-activator.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003707 | molecular_function | nuclear steroid receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003707 | molecular_function | nuclear steroid receptor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue I5W A 501 |
| Chain | Residue |
| A | ILE268 |
| A | VAL342 |
| A | PHE346 |
| A | CYS432 |
| A | HOH670 |
| A | ALA271 |
| A | ALA272 |
| A | GLN275 |
| A | ASN306 |
| A | PHE313 |
| A | ARG316 |
| A | LEU326 |
| A | ALA327 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 502 |
| Chain | Residue |
| A | ARG393 |
| C | ARG421 |
| C | HOH677 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue I5W C 501 |
| Chain | Residue |
| C | ILE268 |
| C | ALA271 |
| C | GLN275 |
| C | ASN306 |
| C | LEU309 |
| C | PHE313 |
| C | ARG316 |
| C | LEU326 |
| C | ALA327 |
| C | PHE346 |
| C | CYS432 |
| C | LEU436 |
| C | HOH674 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 502 |
| Chain | Residue |
| A | ARG421 |
| A | HOH668 |
| C | ARG393 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 |
| Chain | Residue | Details |
| A | ARG316 | |
| A | ALA327 | |
| C | ARG316 | |
| C | ALA327 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER259 | |
| C | SER259 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700 |
| Chain | Residue | Details |
| A | SER260 | |
| C | SER260 |
