1W4S
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4U6A
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4UUH
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![BU of 4uuh by Molmil](/molmil-images/mine/4uuh) | X-ray crystal structure of human TNKS in complex with a small molecule inhibitor | 分子名称: | 1,2-ETHANEDIOL, 5-methyl-3-[4-(piperazin-1-ylmethyl)phenyl]isoquinolin-1(2H)-one, GLYCEROL, ... | 著者 | Oliver, A.W, Rajasekaran, M.B, Pearl, L.H. | 登録日 | 2014-07-28 | 公開日 | 2015-07-08 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1- Ones as Potent and Selective Tankyrase Inhibitors Medchemcommm, 6, 2015
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4UW1
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![BU of 4uw1 by Molmil](/molmil-images/mine/4uw1) | X-ray crystal structure of human TNKS in complex with a small molecule inhibitor | 分子名称: | 1,2-ETHANEDIOL, 3-{4-[(dimethylamino)methyl]phenyl}-5-methoxyisoquinolin-1(2H)-one, GLYCEROL, ... | 著者 | Oliver, A.W, Rajasekaran, M.B, Pearl, L.H. | 登録日 | 2014-08-08 | 公開日 | 2015-07-08 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.37 Å) | 主引用文献 | Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1-Ones as Potent and Selective Tankyrase Inhibitors Medchemcommm, 6, 2015
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1GS0
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3EU7
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2BRF
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2CN8
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2CN5
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2W3O
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2W18
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5HY6
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6RML
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![BU of 6rml by Molmil](/molmil-images/mine/6rml) | Crystal structure of TOPBP1 BRCT0,1,2 in complex with a 53BP1 phosphopeptide | 分子名称: | 53BP1, DNA topoisomerase 2-binding protein 1 | 著者 | Day, M, Oliver, A.W, Pearl, L.H. | 登録日 | 2019-05-07 | 公開日 | 2019-06-12 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint. Elife, 8, 2019
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7AUC
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7AUD
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6RMM
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5ECG
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![BU of 5ecg by Molmil](/molmil-images/mine/5ecg) | Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX) | 分子名称: | Cellular tumor antigen p53, SEP-GLN-GLU-TYR, Tumor suppressor p53-binding protein 1, ... | 著者 | Day, M, Oliver, A.W, Pearl, L.H. | 登録日 | 2015-10-20 | 公開日 | 2015-12-16 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with gamma H2AX. Cell Rep, 13, 2015
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8OK2
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![BU of 8ok2 by Molmil](/molmil-images/mine/8ok2) | Bipartite interaction of TOPBP1 with the GINS complex | 分子名称: | DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, DNA replication complex GINS protein PSF3, ... | 著者 | Day, M, Oliver, A.W, Pearl, L.H. | 登録日 | 2023-03-26 | 公開日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | TopBP1 utilises a bipartite GINS binding mode to support genome replication. Nat Commun, 15, 2024
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7AKO
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![BU of 7ako by Molmil](/molmil-images/mine/7ako) | Crystal structure of CHK1 kinase domain in complex with a CLASPIN phosphopeptide | 分子名称: | 1,2-ETHANEDIOL, Claspin, STAUROSPORINE, ... | 著者 | Day, M, Oliver, A.W, Pearl, L.H. | 登録日 | 2020-10-01 | 公開日 | 2021-04-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein. Structure, 29, 2021
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7AKM
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![BU of 7akm by Molmil](/molmil-images/mine/7akm) | Crystal structure of CHK1 kinase domain in complex with ATPyS | 分子名称: | 1,2-ETHANEDIOL, CITRIC ACID, MAGNESIUM ION, ... | 著者 | Day, M, Oliver, A.W, Pearl, L.H. | 登録日 | 2020-10-01 | 公開日 | 2021-04-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein. Structure, 29, 2021
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7QCD
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7P0L
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7P0J
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![BU of 7p0j by Molmil](/molmil-images/mine/7p0j) | Crystal structure of S.pombe Mdb1 BRCT domains | 分子名称: | CITRIC ACID, DNA damage response protein Mdb1, MAGNESIUM ION, ... | 著者 | Day, M, Oliver, A.W, Pearl, L.H. | 登録日 | 2021-06-29 | 公開日 | 2022-07-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1. DNA Repair (Amst), 108, 2021
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5J3S
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![BU of 5j3s by Molmil](/molmil-images/mine/5j3s) | Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2 in complex with a small molecule inhibitor | 分子名称: | 2,4-dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]-2,3,4,10-tetrahydropyrimido[4,5-b]quinoline-8-carbonitrile, Tyrosyl-DNA phosphodiesterase 2 | 著者 | Hornyak, P, Pearl, L.H, Caldecott, K.W, Oliver, A.W. | 登録日 | 2016-03-31 | 公開日 | 2016-05-04 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochem.J., 473, 2016
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5J42
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![BU of 5j42 by Molmil](/molmil-images/mine/5j42) | Crystal structure of m2hTDP2-CAT in complex with a small molecule inhibitor | 分子名称: | 1,2-ETHANEDIOL, 10-(4-hydroxyphenyl)-2,4-dioxo-2,3,4,10-tetrahydropyrimido[4,5-b]quinoline-8-carbonitrile, GLYCEROL, ... | 著者 | Hornyak, P, Pearl, L.H, Caldecott, K.W, Oliver, A.W. | 登録日 | 2016-03-31 | 公開日 | 2016-05-04 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochem.J., 473, 2016
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