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PDB: 122 件
3VQ2
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BU of 3vq2 by Molmil
Crystal structure of mouse TLR4/MD-2/LPS complex
分子名称: (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Ohto, U, Shimizu, T.
登録日2012-03-17
公開日2012-05-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
Proc.Natl.Acad.Sci.USA, 109, 2012
3W67
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BU of 3w67 by Molmil
Crystal structure of mouse alpha-tocopherol transfer protein in complex with alpha-tocopherol and phosphatidylinositol-(3,4)-bisphosphate
分子名称: (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dibutanoate, Alpha-tocopherol transfer protein
著者Ohto, U, Satow, Y.
登録日2013-02-11
公開日2013-05-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Impaired alpha-TTP-PIPs interaction underlies familial vitamin E deficiency
Science, 340, 2013
3WPF
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BU of 3wpf by Molmil
Crystal structure of mouse TLR9 (unliganded form)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Toll-like receptor 9
著者Ohto, U, Shimizu, T.
登録日2014-01-11
公開日2015-02-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.959 Å)
主引用文献Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3WPB
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BU of 3wpb by Molmil
Crystal structure of horse TLR9 (unliganded form)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ...
著者Ohto, U, Tanji, H, Shimizu, T.
登録日2014-01-11
公開日2015-02-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3W68
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BU of 3w68 by Molmil
Crystal structure of mouse alpha-tocopherol transfer protein in complex with alpha-tocopherol and phosphatidylinositol-(4,5)-bisphosphate
分子名称: (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL, (2R)-3-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1 ,2-DIYL DIBUTANOATE, (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXY BUTOXY)PROPYL BUTYRATE, ...
著者Ohto, U, Satow, Y.
登録日2013-02-11
公開日2013-05-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Impaired alpha-TTP-PIPs interaction underlies familial vitamin E deficiency
Science, 340, 2013
3WPD
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BU of 3wpd by Molmil
Crystal structure of horse TLR9 in complex with inhibitory DNA4084
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*CP*TP*GP*GP*AP*TP*GP*GP*G)-3'), ...
著者Ohto, U, Tanji, H, Shimizu, T.
登録日2014-01-11
公開日2015-02-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3WPG
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BU of 3wpg by Molmil
Crystal structure of mouse TLR9 in complex with inhibitory DNA4084 (form 1)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*CP*TP*GP*GP*AP*TP*GP*GP*GP*AP*A)-3'), SULFATE ION, ...
著者Ohto, U, Shimizu, T.
登録日2014-01-11
公開日2015-02-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.246 Å)
主引用文献Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3WPE
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BU of 3wpe by Molmil
Crystal structure of bovine TLR9 in complex with agonistic DNA1668_12mer
分子名称: DNA (5'-D(*CP*AP*TP*GP*AP*CP*GP*TP*TP*CP*CP*T)-3'), Toll-like receptor 9
著者Ohto, U, Tanji, H, Shimizu, T.
登録日2014-01-11
公開日2015-02-11
最終更新日2015-05-06
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3WPI
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BU of 3wpi by Molmil
Crystal structure of mouse TLR9 in complex with inhibitory DNA_super
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*CP*TP*CP*AP*AP*TP*AP*GP*GP*GP*TP*GP*AP*GP*GP*GP*G)-3'), Toll-like receptor 9
著者Ohto, U, Shimizu, T.
登録日2014-01-11
公開日2015-02-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.246 Å)
主引用文献Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3WPH
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BU of 3wph by Molmil
Crystal structure of mouse TLR9 in complex with inhibitory DNA4084 (form 2)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*CP*TP*GP*GP*AP*TP*GP*GP*GP*AP*A)-3'), SULFATE ION, ...
著者Ohto, U, Shimizu, T.
登録日2014-01-11
公開日2015-02-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.327 Å)
主引用文献Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3WPC
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BU of 3wpc by Molmil
Crystal structure of horse TLR9 in complex with agonistic DNA1668_12mer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*AP*TP*GP*AP*CP*GP*TP*TP*CP*CP*T)-3'), ...
著者Ohto, U, Tanji, H, Shimizu, T.
登録日2014-01-11
公開日2015-02-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
8WX3
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BU of 8wx3 by Molmil
Cryo-EM structure of human SLC15A4 (outward-facing open)
分子名称: Solute carrier family 15 member 4
著者Sakaniwa, K, Zhang, Z, Ohto, U, Shimizu, T.
登録日2023-10-27
公開日2023-12-06
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献Cryo-EM structure of human SLC15A4 (outward-facing open)
To Be Published
8WX2
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BU of 8wx2 by Molmil
Cryo-EM structure of human SLC15A3 (dimer)
分子名称: Solute carrier family 15 member 3
著者Kasai, S, Zhang, Z, Ohto, U, Shimizu, T.
登録日2023-10-27
公開日2023-12-06
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.44 Å)
主引用文献Cryo-EM structure of human SLC15A3 (outward-facing partially occluded)
To Be Published
8WX4
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BU of 8wx4 by Molmil
Cryo-EM structure of human SLC15A4 in complex with Lys-Leu (outward-facing open)
分子名称: LEUCINE, LYSINE, Solute carrier family 15 member 4
著者Sakaniwa, K, Zhang, Z, Ohto, U, Shimizu, T.
登録日2023-10-27
公開日2023-12-13
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Cryo-EM structure of human SLC15A4 in complex with Lys-Leu (outward-facing open)
To Be Published
8HRX
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BU of 8hrx by Molmil
Cryo-EM structure of human NTCP-myr-preS1-YN9048Fab complex
分子名称: Fab heavy chain from antibody IgG clone number YN9048, Fab light chain from antibody IgG clone number YN9048, PreS1 protein (Fragment), ...
著者Asami, J, Shimizu, T, Ohto, U.
登録日2022-12-16
公開日2024-01-17
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (2.89 Å)
主引用文献Structural basis of hepatitis B virus receptor binding.
Nat.Struct.Mol.Biol., 31, 2024
8HRY
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BU of 8hry by Molmil
Cryo-EM structure of human NTCP-myr-preS1-YN9016Fab complex
分子名称: Fab heavy chain from antibody IgG clone number YN9016, Fab light chain from antibody IgG clone number YN9016, Large S protein (Fragment), ...
著者Asami, J, Shimizu, T, Ohto, U.
登録日2022-12-16
公開日2024-01-17
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.11 Å)
主引用文献Structural basis of hepatitis B virus receptor binding.
Nat.Struct.Mol.Biol., 31, 2024
5ZSC
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BU of 5zsc by Molmil
Crystal structure of monkey TLR7 in complex with IMDQ and CCUUCC
分子名称: 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2018-04-28
公開日2019-01-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
3M7O
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BU of 3m7o by Molmil
Crystal structure of mouse MD-1 in complex with phosphatidylcholine
分子名称: (2S)-3-(octadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, ...
著者Harada, H, Ohto, U, Satow, Y.
登録日2010-03-17
公開日2010-06-09
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of mouse MD-1 with endogenous phospholipid bound in its cavity
J.Mol.Biol., 400, 2010
6IF5
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BU of 6if5 by Molmil
Crystal structure of monkey TLR7 in complex with 2',3'-cGMP (Guanosine 2',3'-cyclic phosphate)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-PHOSPHATE-2',3'-CYCLIC PHOSPHATE, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2018-09-18
公開日2019-01-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
7WGE
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BU of 7wge by Molmil
Human NLRP1 complexed with thioredoxin
分子名称: MAGNESIUM ION, NACHT, LRR and PYD domains-containing protein 1, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2021-12-28
公開日2023-07-05
最終更新日2023-10-18
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome.
Nature, 622, 2023
7WBU
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BU of 7wbu by Molmil
Cryo-EM structure of bovine NLRP9
分子名称: ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 9
著者Kamitsukasa, Y, Shimizu, T, Ohto, U.
登録日2021-12-17
公開日2022-04-06
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (3.42 Å)
主引用文献The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function.
Febs Lett., 596, 2022
7WBT
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BU of 7wbt by Molmil
Crystal structure of bovine NLRP9
分子名称: ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 9
著者Kamitsukasa, Y, Shimizu, T, Ohto, U.
登録日2021-12-17
公開日2022-04-06
最終更新日2022-04-27
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function.
Febs Lett., 596, 2022
7WSI
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BU of 7wsi by Molmil
Cryo-EM structure of human NTCP (wild-type) complexed with YN69202Fab
分子名称: Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Sodium/bile acid cotransporter
著者Asami, J, Shimizu, T, Ohto, U.
登録日2022-01-29
公開日2022-05-25
最終更新日2022-07-13
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
6KYA
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BU of 6kya by Molmil
Crystal structure of human TLR8 in complex TH1027
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-methylsulfanyl-4-(3,4,5-trimethylphenyl)-1,2,4-triazol-3-yl]propan-1-ol, ...
著者Tanji, H, Sakaniwa, K, Ohto, U, Shimizu, T.
登録日2019-09-17
公開日2020-05-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface.
J.Med.Chem., 63, 2020
6LVY
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BU of 6lvy by Molmil
Crystal structure of TLR7/Cpd-2 (SM-360320) complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-(2-methoxyethoxy)-9-(phenylmethyl)-7H-purin-8-one, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2020-02-06
公開日2020-11-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020

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