8BA2
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![BU of 8ba2 by Molmil](/molmil-images/mine/8ba2) | Crystal structure of JAK2 JH2-V617F in complex with Z902-A1 | Descriptor: | 6-[[(5-bromanylthiophen-2-yl)methyl-methyl-amino]methyl]-~{N}4-(4-methylphenyl)-1,3,5-triazine-2,4-diamine, ACETATE ION, GLYCEROL, ... | Authors: | Haikarainen, T, Silvennoinen, O. | Deposit date: | 2022-10-11 | Release date: | 2023-02-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain. Pharmaceuticals, 16, 2023
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8BJQ
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![BU of 8bjq by Molmil](/molmil-images/mine/8bjq) | Structure of a yeast 80S ribosome-bound N-Acetyltransferase B complex | Descriptor: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | Authors: | Knorr, A.G, Mackens-Kiani, T, Musial, J, Berninghausen, O, Becker, T, Beatrix, B, Beckmann, R. | Deposit date: | 2022-11-05 | Release date: | 2023-02-08 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | The dynamic architecture of Map1- and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains. Plos Biol., 21, 2023
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7ZMS
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![BU of 7zms by Molmil](/molmil-images/mine/7zms) | Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G4-043 | Descriptor: | ATP-dependent DNA helicase Q5, Gluebody G4-043, ZINC ION | Authors: | Ye, M, Makola, M, Newman, J.A, Fairhead, M, MacLean, E, Krojer, T, Aitkenhead, H, Bountra, C, Gileadi, O, von Delft, F. | Deposit date: | 2022-04-19 | Release date: | 2022-07-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts To Be Published
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7ZW0
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![BU of 7zw0 by Molmil](/molmil-images/mine/7zw0) | FAP-80S Complex - Rotated state | Descriptor: | 18S ribosomal RNA (RDN18-1), 25S ribosomal RNA (RDN25-1), 40S ribosomal protein S0-A, ... | Authors: | Ikeuchi, K, Buschauer, R, Berninghausen, O, Becker, T, Beckmann, R. | Deposit date: | 2022-05-17 | Release date: | 2022-10-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover. Mol.Cell, 82, 2022
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7ZGI
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![BU of 7zgi by Molmil](/molmil-images/mine/7zgi) | chloroplast trigger factor (TIG1) | Descriptor: | DI(HYDROXYETHYL)ETHER, Peptidylprolyl isomerase, SULFATE ION | Authors: | Carius, Y, Ries, F, Gries, K, Trentmann, O, Willmund, F, Lancaster, C.R.D. | Deposit date: | 2022-04-03 | Release date: | 2022-10-12 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural features of chloroplast trigger factor determined at 2.6 angstrom resolution. Acta Crystallogr D Struct Biol, 78, 2022
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8BUX
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![BU of 8bux by Molmil](/molmil-images/mine/8bux) | Rab-binding domain of human MiniBAR | Descriptor: | 1,2-ETHANEDIOL, Granule associated Rac and RHOG effector protein 1, MAGNESIUM ION, ... | Authors: | Pylypenko, O, Hammich, H, Houdusse, A. | Deposit date: | 2022-12-01 | Release date: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | MiniBAR/KIAA0355 is a dual Rac and Rab effector that controls actin contractility
and trafficking for successful ciliogenesis To Be Published
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8BUY
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![BU of 8buy by Molmil](/molmil-images/mine/8buy) | Rac-binding domain of human MiniBAR | Descriptor: | 1,2-ETHANEDIOL, Granule associated Rac and RHOG effector protein 1, SULFATE ION | Authors: | Pylypenko, O, Hammich, H, Houdusse, A. | Deposit date: | 2022-12-01 | Release date: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | MiniBAR/KIAA0355 is a dual Rac and Rab effector that controls actin contractility
and trafficking for successful ciliogenesis To Be Published
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8C0B
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![BU of 8c0b by Molmil](/molmil-images/mine/8c0b) | CryoEM structure of Aspergillus nidulans UTP-glucose-1-phosphate uridylyltransferase | Descriptor: | UTP--glucose-1-phosphate uridylyltransferase | Authors: | Han, X, D Angelo, C, Otamendi, A, Cifuente, J.O, de Astigarraga, E, Ochoa-Lizarralde, B, Grininger, M, Routier, F.H, Guerin, M.E, Fuehring, J, Etxebeste, O, Connell, S.R. | Deposit date: | 2022-12-16 | Release date: | 2023-06-28 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.98 Å) | Cite: | CryoEM analysis of the essential native UDP-glucose pyrophosphorylase from Aspergillus nidulans reveals key conformations for activity regulation and function. Mbio, 14, 2023
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8C5N
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![BU of 8c5n by Molmil](/molmil-images/mine/8c5n) | Sub-atomic resolution structure of the chitin-binding protein D (CbpD) from Pseudomonas aeruginosa | Descriptor: | CHLORIDE ION, Chitin-binding protein CbpD | Authors: | Cordara, G, Krengel, U, Golten, O, Vaaje-Kolstad, G, Vinther Soerensen, H. | Deposit date: | 2023-01-09 | Release date: | 2023-06-28 | Last modified: | 2023-07-26 | Method: | X-RAY DIFFRACTION (0.75 Å) | Cite: | Immunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against Pseudomonas aeruginosa pneumonia. Proc.Natl.Acad.Sci.USA, 120, 2023
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8BYK
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![BU of 8byk by Molmil](/molmil-images/mine/8byk) | The structure of MadC from Clostridium maddingley reveals new insights into class I lanthipeptide cyclases | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Knospe, C.V, Kamel, M, Spitz, O, Hoeppner, A, Galle, S, Reiners, J, Kedrov, A, Smits, S.H, Schmitt, L. | Deposit date: | 2022-12-13 | Release date: | 2023-02-22 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The structure of MadC from Clostridium maddingley reveals new insights into class I lanthipeptide cyclases. Front Microbiol, 13, 2022
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8CDN
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![BU of 8cdn by Molmil](/molmil-images/mine/8cdn) | Crystal structure of human Brachyury in complex with a single T box binding element DNA | Descriptor: | DNA (5'-D(*AP*GP*GP*CP*TP*CP*AP*CP*AP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*TP*GP*TP*GP*AP*GP*CP*CP*T)-3'), T-box transcription factor T | Authors: | Newman, J.A, Gavard, A.E, von Delft, F, Gileadi, O, Bountra, C. | Deposit date: | 2023-01-31 | Release date: | 2023-03-22 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Crystal structure of human Brachyury in complex with a single T box binding element DNA To Be Published
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5MDU
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![BU of 5mdu by Molmil](/molmil-images/mine/5mdu) | Structure of the RNA recognition motif (RRM) of Seb1 from S. pombe. | Descriptor: | CHLORIDE ION, GLYCEROL, Rpb7-binding protein seb1, ... | Authors: | Wittmann, S, Renner, M, El Omari, K, Adams, O, Vasiljeva, L, Grimes, J. | Deposit date: | 2016-11-13 | Release date: | 2017-04-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.02 Å) | Cite: | The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA. Nat Commun, 8, 2017
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5MKQ
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![BU of 5mkq by Molmil](/molmil-images/mine/5mkq) | TtuA enzyme containing a [4Fe-4S] | Descriptor: | IRON/SULFUR CLUSTER, TtuA PH0300, ZINC ION | Authors: | Arragain, S, Bimai, O, Legrand, P, Golinelli-Pimpaneau, B. | Deposit date: | 2016-12-05 | Release date: | 2017-06-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Nonredox thiolation in tRNA occurring via sulfur activation by a [4Fe-4S] cluster. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5MQ9
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![BU of 5mq9 by Molmil](/molmil-images/mine/5mq9) | Crystal structure of Rae1 (YacP) from Bacillus subtilis (W164L mutant) | Descriptor: | SULFATE ION, Uncharacterized protein YacP | Authors: | Piton, J, Gilet, L, Pellegrini, O, Leroy, M, Figaro, S, Condon, C. | Deposit date: | 2016-12-20 | Release date: | 2017-04-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.174 Å) | Cite: | Rae1/YacP, a new endoribonuclease involved in ribosome-dependent mRNA decay in Bacillus subtilis. EMBO J., 36, 2017
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5MVJ
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![BU of 5mvj by Molmil](/molmil-images/mine/5mvj) | |
3OD6
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![BU of 3od6 by Molmil](/molmil-images/mine/3od6) | Crystal structure of p38alpha Y323T active mutant | Descriptor: | Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | Authors: | Livnah, O, Tzarum, N. | Deposit date: | 2010-08-11 | Release date: | 2011-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.682 Å) | Cite: | Active mutants of the TCR-mediated p38alpha alternative activation site show changes in the phosphorylation lip and DEF site formation. J.Mol.Biol., 405, 2011
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3O9M
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![BU of 3o9m by Molmil](/molmil-images/mine/3o9m) | Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification | Descriptor: | BENZOIC ACID, Cholinesterase | Authors: | Asojo, O.A, Ngamelue, M.N, Homma, K, Lockridge, O. | Deposit date: | 2010-08-04 | Release date: | 2011-04-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Cocrystallization studies of full-length recombinant butyrylcholinesterase (BChE) with cocaine. Acta Crystallogr.,Sect.F, 67, 2011
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5MKP
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![BU of 5mkp by Molmil](/molmil-images/mine/5mkp) | Non redox thiolation in transfer RNAs occuring via sulfur activation by a [4Fe-4S] cluster | Descriptor: | Fe4 H S5, PH0300, ZINC ION | Authors: | Arragain, S, Bimai, O, Legrand, P, Golinelli-Pimpaneau, B. | Deposit date: | 2016-12-05 | Release date: | 2017-06-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Nonredox thiolation in tRNA occurring via sulfur activation by a [4Fe-4S] cluster. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5MTV
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![BU of 5mtv by Molmil](/molmil-images/mine/5mtv) | Active structure of EHD4 complexed with ATP-gamma-S | Descriptor: | EH domain-containing protein 4, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | Authors: | Melo, A.A, Daumke, O. | Deposit date: | 2017-01-10 | Release date: | 2017-03-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Structural insights into the activation mechanism of dynamin-like EHD ATPases. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3NVJ
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![BU of 3nvj by Molmil](/molmil-images/mine/3nvj) | Crystal structure of the C143A/C166A mutant of Ero1p | Descriptor: | 1-ETHYL-PYRROLIDINE-2,5-DIONE, CADMIUM ION, Endoplasmic oxidoreductin-1, ... | Authors: | Fass, D, Vonshak, O. | Deposit date: | 2010-07-08 | Release date: | 2010-11-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Steps in reductive activation of the disulfide-generating enzyme Ero1p Protein Sci., 19, 2010
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5MAQ
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![BU of 5maq by Molmil](/molmil-images/mine/5maq) | Crystal Structure of Polyphosphate Kinase from Meiothermus ruber bound to ADP and PPi | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PYROPHOSPHATE, ... | Authors: | Gerhardt, S, Einsle, O, Kemper, F, Schwarzer, N. | Deposit date: | 2016-11-04 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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3NR9
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![BU of 3nr9 by Molmil](/molmil-images/mine/3nr9) | Structure of human CDC2-like kinase 2 (CLK2) | Descriptor: | (5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Dual specificity protein kinase CLK2 | Authors: | Chaikuad, A, Savitsky, P, Krojer, T, Muniz, J.R.C, Filippakopoulos, P, Rellos, P, Keates, T, Fedorov, O, Pike, A.C.W, Eswaran, J, Berridge, G, Phillips, C, Zhang, Y, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2010-06-30 | Release date: | 2010-08-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Structure of human CDC2-like kinase 2 (CLK2) To be Published
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3ZEB
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![BU of 3zeb by Molmil](/molmil-images/mine/3zeb) | A complex of GlpG with isocoumarin inhibitor covalently bonded to serine 201 and histidine 150 | Descriptor: | 2-phenylethyl 2-(4-azanyl-2-methanoyl-phenyl)ethanoate, CHLORIDE ION, RHOMBOID PROTEASE GLPG, ... | Authors: | Vinothkumar, K.R, voskya, O, Kuettler, E.V, Brouwer, A.J, Liskamp, R.M.J, Verhelst, S.H.L. | Deposit date: | 2012-12-04 | Release date: | 2013-02-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Activity-Based Probes for Rhomboid Proteases Discovered in a Mass Spectrometry-Based Assay. Proc.Natl.Acad.Sci.USA, 110, 2013
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3O87
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![BU of 3o87 by Molmil](/molmil-images/mine/3o87) | Crystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitor | Descriptor: | 4-({[(dihydroxyboranyl)methyl]sulfamoyl}methyl)benzoic acid, Beta-lactamase, PHOSPHATE ION | Authors: | Eidam, O, Romagnoli, C, Karpiak, J, Shoichet, B.K. | Deposit date: | 2010-08-02 | Release date: | 2010-11-03 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Design, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as beta-Lactamase Inhibitors J.Med.Chem., 53, 2010
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5MTN
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![BU of 5mtn by Molmil](/molmil-images/mine/5mtn) | Monobody Mb(Lck_1) bound to Lck-Sh2 | Descriptor: | Monobody Mb(Lck_1), SULFATE ION, Tyrosine-protein kinase Lck | Authors: | Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O. | Deposit date: | 2017-01-10 | Release date: | 2017-04-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017
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