5MTV

Active structure of EHD4 complexed with ATP-gamma-S

Summary for 5MTV

Entry DOI	10.2210/pdb5mtv/pdb
Descriptor	EH domain-containing protein 4, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	dynamin-like, membrane protein, auto-inhibition, activation, endocytosis
Biological source	Mus musculus (House Mouse)
Cellular location	Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side : Q9EQP2
Total number of polymer chains	1
Total formula weight	60035.63
Authors	Melo, A.A.,Daumke, O. (deposition date: 2017-01-10, release date: 2017-03-08, Last modification date: 2024-01-17)
Primary citation	Melo, A.A.,Hegde, B.G.,Shah, C.,Larsson, E.,Isas, J.M.,Kunz, S.,Lundmark, R.,Langen, R.,Daumke, O. Structural insights into the activation mechanism of dynamin-like EHD ATPases. Proc. Natl. Acad. Sci. U.S.A., 114:5629-5634, 2017 Cited by PubMed: 28228524 DOI: 10.1073/pnas.1614075114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.79 Å)

Structure validation