8BA2

Crystal structure of JAK2 JH2-V617F in complex with Z902-A1

Summary for 8BA2

Entry DOI	10.2210/pdb8ba2/pdb
Descriptor	Tyrosine-protein kinase JAK2, GLYCEROL, ACETATE ION, ... (5 entities in total)
Functional Keywords	janus kinase, pseudokinase, inhibitor complex, jak2, jh2, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34166.90
Authors	Haikarainen, T.,Silvennoinen, O. (deposition date: 2022-10-11, release date: 2023-02-01, Last modification date: 2024-02-07)
Primary citation	Virtanen, A.T.,Haikarainen, T.,Sampathkumar, P.,Palmroth, M.,Liukkonen, S.,Liu, J.,Nekhotiaeva, N.,Hubbard, S.R.,Silvennoinen, O. Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain. Pharmaceuticals, 16:-, 2023 Cited by PubMed: 36678572 DOI: 10.3390/ph16010075 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation