8BA2

Crystal structure of JAK2 JH2-V617F in complex with Z902-A1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosine-protein kinase JAK2	polymer	289	33169.0	1	UniProt (O60674) Pfam (PF07714)	Homo sapiens (human)	Janus kinase 2,JAK-2
2	B, C, D, G, I (A)	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
3	E, F (A)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
4	H (A)	6-[[(5-bromanylthiophen-2-yl)methyl-methyl-amino]methyl]-~{N}4-(4-methylphenyl)-1,3,5-triazine-2,4-diamine	non-polymer		419.3	1	Chemie (Q9X)
5	J (A)	water	water		18.0	284	Chemie (HOH)

Sequence modifications

A: 536 - 812 (UniProt: O60674)

PDB	External Database	Details
Phe 617	Val 617	variant
Ala 659	Trp 659	engineered mutation
Ala 777	Trp 777	engineered mutation
His 794	Phe 794	engineered mutation
Leu 813	-	expression tag
Val 814	-	expression tag
Pro 815	-	expression tag
Arg 816	-	expression tag
Gly 817	-	expression tag
Ser 818	-	expression tag
His 819	-	expression tag
His 820	-	expression tag
His 821	-	expression tag
His 822	-	expression tag
His 823	-	expression tag
His 824	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33169.0
Non-Polymers*	Number of molecules	8
	Total formula weight	997.9
All*	Total formula weight	34166.9

*Water molecules are not included.