1IKF
 
 | | A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX | | 分子名称: | CYCLOSPORIN A, IGG1-KAPPA R45-45-11 FAB (HEAVY CHAIN), IGG1-KAPPA R45-45-11 FAB (LIGHT CHAIN) | | 著者 | Vix, O, Altschuh, D, Rees, B, Thierry, J.-C. | | 登録日 | 1993-12-09 | | 公開日 | 1995-03-31 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A Conformation of Cyclosporin a in Aqueous Environment Revealed by the X-Ray Structure of a Cyclosporin-Fab Complex.
Science, 256, 1992
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1JDE
 | | K22A mutant of pyruvate, phosphate dikinase | | 分子名称: | PYRUVATE, PHOSPHATE DIKINASE, SULFATE ION | | 著者 | Ye, D, Wei, M, McGuire, M, Huang, K, Kapadia, G, Herzberg, O, Martin, B.M, Dunaway-Mariano, D. | | 登録日 | 2001-06-13 | | 公開日 | 2001-11-28 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Investigation of the catalytic site within the ATP-grasp domain of Clostridium symbiosum pyruvate phosphate dikinase.
J.Biol.Chem., 276, 2001
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6QF4
 | | X-Ray structure of human Serine/Threonine Kinase 17B (STK17B) aka DRAK2 in complex with ADP obtained by on-chip soaking | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... | | 著者 | Lieske, J, Cerv, M, Kreida, S, Barthelmess, M, Fischer, P, Pakendorf, T, Yefanov, O, Mariani, V, Seine, T, Ross, B.H, Crosas, E, Lorbeer, O, Burkhardt, A, Lane, T.J, Guenther, S, Bergtholdt, J, Schoen, S, Tornroth-Horsefield, S, Chapman, H.N, Meents, A. | | 登録日 | 2019-01-09 | | 公開日 | 2019-07-10 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.495 Å) | | 主引用文献 | On-chip crystallization for serial crystallography experiments and on-chip ligand-binding studies.
Iucrj, 6, 2019
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6QF5
 | | X-Ray structure of human Aquaporin 2 crystallized on a silicon chip | | 分子名称: | Aquaporin-2, CADMIUM ION | | 著者 | Lieske, J, Cerv, M, Kreida, S, Barthelmess, M, Fischer, P, Pakendorf, T, Yefanov, O, Mariani, V, Seine, T, Ross, B.H, Crosas, E, Lorbeer, O, Burkhardt, A, Lane, T.J, Guenther, S, Bergtholdt, J, Schoen, S, Tornroth-Horsefield, S, Chapman, H.N, Meents, A. | | 登録日 | 2019-01-09 | | 公開日 | 2019-07-10 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | On-chip crystallization for serial crystallography experiments and on-chip ligand-binding studies.
Iucrj, 6, 2019
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7B05
 | | TRPC4 in complex with inhibitor GFB-8749 | | 分子名称: | (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, 4-[4-[[4,4-bis(fluoranyl)cyclohexyl]methyl]-3-oxidanylidene-piperazin-1-yl]-5-chloranyl-1~{H}-pyridazin-6-one, CALCIUM ION, ... | | 著者 | Vinayagam, D, Quentin, D, Sistel, O, Merino, F, Stabrin, M, Hofnagel, O, Ledeboer, M.W, Malojcic, G, Raunser, S. | | 登録日 | 2020-11-18 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural basis of TRPC4 regulation by calmodulin and pharmacological agents.
Elife, 9, 2020
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2RIK
 | | I-band fragment I67-I69 from titin | | 分子名称: | Titin | | 著者 | Marino, M, von Castelmur, E, Labeit, D, Labeit, S, Mayans, O. | | 登録日 | 2007-10-11 | | 公開日 | 2008-01-22 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain
Proc.Natl.Acad.Sci.Usa, 105, 2008
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4BEJ
 | | Nucleotide-free Dynamin 1-like protein (DNM1L, DRP1, DLP1) | | 分子名称: | DYNAMIN 1-LIKE PROTEIN | | 著者 | Froehlich, C, Schwefel, D, Faelber, K, Daumke, O. | | 登録日 | 2013-03-11 | | 公開日 | 2013-04-24 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.483 Å) | | 主引用文献 | Structural Insights Into Oligomerization and Mitochondrial Remodelling of Dynamin 1-Like Protein.
Embo J., 32, 2013
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2RJM
 | | 3Ig structure of titin domains I67-I69 E-to-A mutated variant | | 分子名称: | Titin | | 著者 | von Castelmur, E, Marino, M, Labeit, D, Labeit, S, Mayans, O. | | 登録日 | 2007-10-15 | | 公開日 | 2008-01-22 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain
Proc.Natl.Acad.Sci.Usa, 105, 2008
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4C66
 | | Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains | | 分子名称: | 4-(2-chlorophenyl)-2-ethyl-9-methyl-6,8-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, BROMODOMAIN-CONTAINING PROTEIN 4 | | 著者 | Chung, C, Mirguet, O. | | 登録日 | 2013-09-17 | | 公開日 | 2013-10-02 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Discovery of Epigenetic Regulator I-Bet762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the Bet Bromodomains.
J.Med.Chem., 56, 2013
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2VCA
 | | Family 89 glycoside hydrolase from Clostridium perfringens in complex with beta-N-acetyl-D-glucosamine | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-N-ACETYLGLUCOSAMINIDASE, CALCIUM ION, ... | | 著者 | Ficko-Blean, E, Stubbs, K.A, Berg, O, Vocadlo, D.J, Boraston, A.B. | | 登録日 | 2007-09-19 | | 公開日 | 2008-03-18 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structural and Mechanistic Insight Into the Basis of Mucopolysaccharidosis Iiib.
Proc.Natl.Acad.Sci.USA, 105, 2008
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7O85
 | | Anthrax toxin prepore in complex with the neutralizing Fab cAb29 | | 分子名称: | CALCIUM ION, Fab, Protective antigen PA-63 | | 著者 | Hoelzgen, F, Zalk, R, Alcalay, R, Cohen-Schwartz, S, Garau, G, Shahar, A, Mazor, O, Frank, G.A. | | 登録日 | 2021-04-14 | | 公開日 | 2021-04-28 | | 最終更新日 | 2021-09-29 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Neutralization of the anthrax toxin by antibody-mediated stapling of its membrane-penetrating loop.
Acta Crystallogr D Struct Biol, 77, 2021
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4KPP
 | | Crystal Structure of H+/Ca2+ Exchanger CAX | | 分子名称: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, OLEIC ACID, ... | | 著者 | Nishizawa, T, Ishitani, R, Nureki, O. | | 登録日 | 2013-05-14 | | 公開日 | 2013-06-26 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural basis for the counter-transport mechanism of a H+/Ca2+ exchanger.
Science, 341, 2013
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2BMI
 | | METALLO-BETA-LACTAMASE | | 分子名称: | PROTEIN (CLASS B BETA-LACTAMASE), SODIUM ION, ZINC ION | | 著者 | Carfi, A, Duee, E, Dideberg, O. | | 登録日 | 1998-09-17 | | 公開日 | 1998-09-23 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | X-ray structure of the ZnII beta-lactamase from Bacteroides fragilis in an orthorhombic crystal form.
Acta Crystallogr.,Sect.D, 54, 1998
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2C30
 | | Crystal Structure Of The Human P21-Activated Kinase 6 | | 分子名称: | CHLORIDE ION, PHOSPHATE ION, SERINE/THREONINE-PROTEIN KINASE PAK 6 | | 著者 | Filippakopoulos, P, Berridge, G, Bray, J, Burgess, N, Colebrook, S, Das, S, Eswaran, J, Gileadi, O, Papagrigoriou, E, Savitsky, P, Smee, C, Turnbull, A, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, von Delft, F, Knapp, S. | | 登録日 | 2005-10-02 | | 公開日 | 2006-02-08 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal Structures of the P21-Activated Kinases Pak4, Pak5, and Pak6 Reveal Catalytic Domain Plasticity of Active Group II Paks.
Structure, 15, 2007
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2BLM
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3CV7
 | | Crystal structure of porcine aldehyde reductase ternary complex | | 分子名称: | 3,5-dichloro-2-hydroxybenzoic acid, Alcohol dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Carbone, V, El-Kabbani, O. | | 登録日 | 2008-04-18 | | 公開日 | 2008-10-28 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.412 Å) | | 主引用文献 | Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20alpha-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: Implications for inhibitor binding and selectivity
Arch.Biochem.Biophys., 479, 2008
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3D05
 | | Human p53 core domain with hot spot mutation R249S (II) | | 分子名称: | Cellular tumor antigen p53, ZINC ION | | 著者 | Suad, O, Rozenberg, H, Shimon, L.J.W, Frolow, F, Shakked, Z. | | 登録日 | 2008-05-01 | | 公開日 | 2009-01-20 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations
J.Mol.Biol., 385, 2009
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3CL9
 | | Structure of bifunctional TcDHFR-TS in complex with MTX | | 分子名称: | 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS), ... | | 著者 | Schormann, N, Senkovich, O, Chattopadhyay, D. | | 登録日 | 2008-03-18 | | 公開日 | 2009-01-06 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function.
Proteins, 73, 2008
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3CRE
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3CSO
 | | HCV Polymerase in complex with a 1,5 Benzodiazepine inhibitor | | 分子名称: | (11S)-10-acetyl-11-[4-(benzyloxy)-3-chlorophenyl]-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one, RNA-directed RNA polymerase | | 著者 | Nyanguile, O. | | 登録日 | 2008-04-10 | | 公開日 | 2009-04-14 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | 1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.
Antimicrob.Agents Chemother., 52, 2008
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3DDT
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3DAG
 | | The crystal structure of [Fe]-hydrogenase holoenzyme (HMD) from METHANOCALDOCOCCUS JANNASCHII | | 分子名称: | 5'-O-[(S)-{[2-(carboxymethyl)-6-hydroxy-3,5-dimethylpyridin-4-yl]oxy}(hydroxy)phosphoryl]guanosine, 5,10-methenyltetrahydromethanopterin hydrogenase, CARBON MONOXIDE, ... | | 著者 | Pilak, O, Warkentin, E, Shima, S, Thauer, R.K, Ermler, U. | | 登録日 | 2008-05-29 | | 公開日 | 2008-12-09 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | The crystal structure of [Fe]-hydrogenase reveals the geometry of the active site.
Science, 321, 2008
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3D91
 | | Human renin in complex with remikiren | | 分子名称: | DIMETHYL SULFOXIDE, Nalpha-[(2S)-2-benzyl-3-(tert-butylsulfonyl)propanoyl]-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-L-histidinamide, Renin | | 著者 | Prade, L, Bezencon, O, Bur, D, Weller, T, Fischli, W, Remen, L. | | 登録日 | 2008-05-26 | | 公開日 | 2008-06-17 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Human renin in complex with remikiren
to be published
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3DDC
 | | Crystal Structure of NORE1A in Complex with RAS | | 分子名称: | GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | 著者 | Stieglitz, B, Bee, C, Schwarz, D, Yildiz, O, Moshnikova, A, Khokhlatchev, A, Herrmann, C. | | 登録日 | 2008-06-05 | | 公開日 | 2008-07-15 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II
Embo J., 27, 2008
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3DAF
 | | The crystal structure of [Fe]-hydrogenase holoenzyme (HMD) from METHANOCALDOCOCCUS JANNASCHII cocrystallized with cyanide | | 分子名称: | 5'-O-[(S)-{[2-(carboxymethyl)-6-hydroxy-3,5-dimethylpyridin-4-yl]oxy}(hydroxy)phosphoryl]guanosine, 5,10-methenyltetrahydromethanopterin hydrogenase, CARBON MONOXIDE, ... | | 著者 | Pilak, O, Warkentin, E, Shima, S, Thauer, R.K, Ermler, U. | | 登録日 | 2008-05-29 | | 公開日 | 2008-12-09 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | The crystal structure of [Fe]-hydrogenase reveals the geometry of the active site.
Science, 321, 2008
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