3CL9

Structure of bifunctional TcDHFR-TS in complex with MTX

Summary for 3CL9

Entry DOI	10.2210/pdb3cl9/pdb
Related	2H2Q 3CLB
Descriptor	Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS), SULFATE ION, CHLORIDE ION, ... (8 entities in total)
Functional Keywords	bifunctional enzyme in complex with nadp, mtx and dump, methyltransferase, multifunctional enzyme, nucleotide biosynthesis, one-carbon metabolism, oxidoreductase, transferase, oxidoreductase-transferase complex
Biological source	Trypanosoma cruzi
Total number of polymer chains	1
Total formula weight	60832.72
Authors	Schormann, N.,Senkovich, O.,Chattopadhyay, D. (deposition date: 2008-03-18, release date: 2009-01-06, Last modification date: 2023-08-30)
Primary citation	Schormann, N.,Senkovich, O.,Walker, K.,Wright, D.L.,Anderson, A.C.,Rosowsky, A.,Ananthan, S.,Shinkre, B.,Velu, S.,Chattopadhyay, D. Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function. Proteins, 73:889-901, 2008 Cited by PubMed: 18536013 DOI: 10.1002/prot.22115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation