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PDB: 17204 件

6FWW
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GFP/KKK. A redesigned GFP with improved solubility
分子名称: Green fluorescent protein
著者Varejao, N, Lascorz, J, Gil-Garcia, M, Diaz-Caballero, M, Navarro, S, Ventura, S, Reverter, D.
登録日2018-03-07
公開日2018-08-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.131 Å)
主引用文献Combining Structural Aggregation Propensity and Stability Predictions To Redesign Protein Solubility.
Mol. Pharm., 15, 2018
6FUH
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Complement factor D in complex with the inhibitor (4-((3-(aminomethyl)phenyl)amino)quinazolin-2-yl)-L-valine
分子名称: (2~{S})-2-[[4-[[3-(aminomethyl)phenyl]amino]quinazolin-2-yl]amino]-3-methyl-butanoic acid, Complement factor D
著者Mac Sweeney, A, Ostermann, N, Vulpetti, A, Maibaum, J, Erbel, P, Lorthiois, E, Yoon, T, Randl, S, Ruedisser, S.
登録日2018-02-27
公開日2018-06-06
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.
ACS Med Chem Lett, 9, 2018
6CS1
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SARS Spike Glycoprotein, Trypsin-cleaved, Stabilized variant, two S1 CTDs in an upwards conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin, ...
著者Kirchdoerfer, R.N, Wang, N, Pallesen, J, Turner, H.L, Cottrell, C.A, McLellan, J.S, Ward, A.B.
登録日2018-03-19
公開日2018-04-11
最終更新日2024-10-30
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis.
Sci Rep, 8, 2018
1AHK
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DER F 2, THE MAJOR MITE ALLERGEN FROM DERMATOPHAGOIDES FARINAE, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称: DER F 2
著者Ichikawa, S, Hatanaka, H, Yuuki, T, Iwamoto, N, Ogura, K, Okumura, Y, Inagaki, F.
登録日1997-04-07
公開日1998-04-08
最終更新日2024-10-30
実験手法SOLUTION NMR
主引用文献Solution structure of Der f 2, the major mite allergen for atopic diseases.
J.Biol.Chem., 273, 1998
5DE5
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BU of 5de5 by Molmil
Crystal structure of the complex between human FMRP RGG motif and G-quadruplex RNA.
分子名称: Fragile X mental retardation protein 1, POTASSIUM ION, sc1
著者Vasilyev, N, Polonskaia, A, Darnell, J.C, Darnell, R.B, Patel, D.J, Serganov, A.
登録日2015-08-25
公開日2015-09-23
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.0011 Å)
主引用文献Crystal structure reveals specific recognition of a G-quadruplex RNA by a beta-turn in the RGG motif of FMRP.
Proc.Natl.Acad.Sci.USA, 112, 2015
6CIH
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Crystal structure of a group II intron lariat in the post-catalytic state
分子名称: IRIDIUM HEXAMMINE ION, MAGNESIUM ION, RNA (5'-R(P*UP*GP*UP*UP*UP*AP*UP*UP*AP*AP*AP*AP*AP*C*-3'), ...
著者Chan, R.T, Peters, J.K, Robart, A.R, Wiryaman, T, Rajashankar, K.R, Toor, N.
登録日2018-02-23
公開日2018-11-21
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3.676 Å)
主引用文献Structural basis for the second step of group II intron splicing.
Nat Commun, 9, 2018
6V70
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Crystal Structure of Metallo Beta Lactamase from Hirschia baltica with Cadmium in the Active Site
分子名称: 1,2-ETHANEDIOL, Beta-lactamase, CADMIUM ION, ...
著者Maltseva, N, Kim, Y, Clancy, S, Endres, M, Mulligan, R, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2019-12-06
公開日2019-12-25
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal Structure of Metallo Beta Lactamase from Hirschia baltica.
To Be Published
5DA8
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Crystal structure of chaperonin GroEL from
分子名称: 60 kDa chaperonin, CALCIUM ION, MAGNESIUM ION, ...
著者Chang, C, Marshall, N, Feldmann, B, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
登録日2015-08-19
公開日2015-10-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of chaperonin GroEL from
To Be Published
6G1V
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Crystal structure of Torpedo Californica acetylcholinesterase in complex with 12-Amino-3-chloro-6,7,10,11-tetrahydro-5,9-dimethyl-7,11-methanocycloocta[b]quinolin-5-ium
分子名称: 12-Amino-3-chloro-6,7,10,11-tetrahydro-5,9-dimethyl-7,11-methanocycloocta[b]quinolin-5-ium, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, ...
著者Coquelle, N, Colletier, J.P.
登録日2018-03-22
公開日2018-04-04
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis.
Molecules, 23, 2018
5DGJ
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1.0A resolution structure of Norovirus 3CL protease in complex an oxadiazole-based, cell permeable macrocyclic (20-mer) inhibitor
分子名称: 3C-LIKE PROTEASE, tert-butyl [(4S,7S,10S)-7-(cyclohexylmethyl)-10-(hydroxymethyl)-5,8,13-trioxo-22-oxa-6,9,14,20,21-pentaazabicyclo[17.2.1]docosa-1(21),19-dien-4-yl]carbamate
著者Lovell, S, Battaile, K.P, Mehzabeen, N, Damalanka, V.C, Kim, Y, Alliston, K.R, Weerawarna, P.M, Kankanamalage, A.C.G, Lushington, G.H, Chang, K.-O, Groutas, W.C.
登録日2015-08-27
公開日2016-02-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1 Å)
主引用文献Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease.
J.Med.Chem., 59, 2016
6FRK
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Structure of a prehandover mammalian ribosomal SRP and SRP receptor targeting complex
分子名称: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
著者Kobayashi, K, Jomaa, A, Ban, N.
登録日2018-02-16
公開日2018-03-28
最終更新日2018-05-02
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structure of a prehandover mammalian ribosomal SRP·SRP receptor targeting complex.
Science, 360, 2018
6PBC
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BU of 6pbc by Molmil
Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations
分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, SODIUM ION
著者Hajicek, N, Sondek, J.
登録日2019-06-13
公開日2020-01-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations.
Elife, 8, 2019
5CQ5
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BU of 5cq5 by Molmil
Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with 2,3-Ethylenedioxybenzoic Acid (SGC - Diamond I04-1 fragment screening)
分子名称: 1,2-ETHANEDIOL, 2,3-dihydro-1,4-benzodioxine-5-carboxylic acid, Bromodomain adjacent to zinc finger domain protein 2B
著者Bradley, A, Pearce, N, Krojer, T, Ng, J, Talon, R, Vollmar, M, Jose, B, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC)
登録日2015-07-21
公開日2015-09-09
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.961 Å)
主引用文献Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with 2,3-Ethylenedioxybenzoic Acid (SGC - Diamond I04-1 fragment screening)
To be published
6G8G
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BU of 6g8g by Molmil
Flavonoid-responsive Regulator FrrA in complex with Genistein
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GENISTEIN, TetR/AcrR family transcriptional regulator
著者Werner, N, Hoppen, J, Palm, G, Werten, S, Goettfert, M, Hinrichs, W.
登録日2018-04-08
公開日2019-04-17
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The induction mechanism of the flavonoid-responsive regulator FrrA.
Febs J., 2021
6FZJ
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BU of 6fzj by Molmil
PPAR gamma mutant complex
分子名称: (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid, CHLORIDE ION, IODIDE ION, ...
著者Rochel, N.
登録日2018-03-14
公開日2019-02-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.011 Å)
主引用文献Recurrent activating mutations of PPAR gamma associated with luminal bladder tumors.
Nat Commun, 10, 2019
6P6D
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BU of 6p6d by Molmil
HUMAN IGG1 FC FRAGMENT, C239 INSERTION MUTANT
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, IgG1 Fc fragment
著者Gallagher, D.T, Dimasi, N, McCullough, C.
登録日2019-06-03
公開日2020-04-15
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions.
Pharmaceutics, 11, 2019
1PS3
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Golgi alpha-mannosidase II in complex with kifunensine
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-mannosidase II, ...
著者Shah, N, Kuntz, D.A, Rose, D.R.
登録日2003-06-20
公開日2003-12-16
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Comparison of Kifunensine and 1-Deoxymannojirimycin Binding to Class I and II alpha-Mannosidases Demonstrates Different Saccharide Distortions in Inverting and Retaining Catalytic Mechanisms
Biochemistry, 42, 2003
6G5P
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BU of 6g5p by Molmil
Crystal structure of human SP100 in complex with bromodomain-focused fragment FM009493b 2,3-Dimethoxy-2,3-dimethyl-2,3-dihydro-1,4-benzodioxin-6-amine
分子名称: (2~{R},3~{R})-2,3-dimethoxy-2,3-dimethyl-1,4-benzodioxin-6-amine, 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
著者Talon, R.P.H, Krojer, T, Tallant, C, Nunez-Alonso, G, Fairhead, M, Szykowska, A, Collins, P, Pearce, N.M, Ng, J, MacLean, E, Wright, N, Douangamath, A, Brandao-Neto, J, Burgess-Brown, N, Huber, K, Knapp, S, Brennan, P.E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F.
登録日2018-03-29
公開日2018-04-11
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces
Biorxiv, 2018
6CMC
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BU of 6cmc by Molmil
Barium sites in the structure of a desensitized acid sensing ion channel
分子名称: Acid-sensing ion channel 1, CHLORIDE ION
著者Yoder, N, Gouaux, E.
登録日2018-03-03
公開日2018-08-08
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.671 Å)
主引用文献Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography.
PLoS ONE, 13, 2018
1PVV
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Refined Structure of Pyrococcus furiosus Ornithine Carbamoyltransferase at 1.87 A
分子名称: Ornithine carbamoyltransferase, SULFATE ION
著者Massant, J, Wouters, J, Glansdorff, N.
登録日2003-06-29
公開日2003-12-09
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Refined structure of Pyrococcus furiosus ornithine carbamoyltransferase at 1.87 A.
Acta Crystallogr.,Sect.D, 59, 2003
6PDN
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BU of 6pdn by Molmil
Human PIM1 bound to benzothiophene inhibitor 292
分子名称: 4-{5-[(3-aminopropyl)carbamoyl]thiophen-2-yl}-1-benzothiophene-2-carboxylic acid, GLYCEROL, Serine/threonine-protein kinase pim-1, ...
著者Godoi, P.H.C, Santiago, A.S, Fala, A.M, Ramos, P.Z, Sriranganadane, D, Mascarello, A, Segretti, N, Azevedo, H, Guimaraes, C.R.W, Arruda, P, Elkins, J.M, Counago, R.M, Structural Genomics Consortium (SGC)
登録日2019-06-19
公開日2019-07-24
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Human PIM1
To Be Published
6PDO
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BU of 6pdo by Molmil
Human PIM1 bound to benzothiophene inhibitor 354
分子名称: 4-{5-[(3-aminopropyl)carbamoyl]thiophen-2-yl}-1-benzothiophene-2-carboxamide, Peptide, Serine/threonine-protein kinase pim-1
著者Godoi, P.H.C, Santiago, A.S, Fala, A.M, Ramos, P.Z, Sriranganadane, D, Mascarello, A, Segretti, N, Azevedo, H, Guimaraes, C.R.W, Arruda, P, Elkins, J.M, Counago, R.M, Structural Genomics Consortium (SGC)
登録日2019-06-19
公開日2019-07-24
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Human PIM1
To Be Published
6PPR
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BU of 6ppr by Molmil
Cryo-EM structure of AdnA(D934A)-AdnB(D1014A) in complex with AMPPNP and DNA
分子名称: ATP-dependent DNA helicase (UvrD/REP), DNA (70-MER), IRON/SULFUR CLUSTER, ...
著者Jia, N, Unciuleac, M, Shuman, S, Patel, D.J.
登録日2019-07-08
公開日2019-11-20
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection.
Proc.Natl.Acad.Sci.USA, 116, 2019
6UX3
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BU of 6ux3 by Molmil
Crystal structure of acetoin dehydrogenase from Enterobacter cloacae
分子名称: Acetoin dehydrogenase, DI(HYDROXYETHYL)ETHER, GLYCEROL
著者Chang, C, Skarina, T, Mesa, N, Savchenko, A, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2019-11-06
公開日2019-11-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.198 Å)
主引用文献Crystal structure of acetoin dehydrogenase from Enterobacter cloacae
To Be Published
6V0C
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Lipophilic Envelope-spanning Tunnel B (LetB), Model 1
分子名称: Intermembrane transport protein YebT
著者Isom, G.L, Coudray, N, MacRae, M.R, McManus, C.T, Ekiert, D.C, Bhabha, G.
登録日2019-11-18
公開日2020-05-06
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献LetB Structure Reveals a Tunnel for Lipid Transport across the Bacterial Envelope.
Cell, 181, 2020

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