6PDO

Human PIM1 bound to benzothiophene inhibitor 354

Summary for 6PDO

Related6PCW 6PDI 6PDN
DescriptorSerine/threonine-protein kinase pim-1, Peptide, 4-{5-[(3-aminopropyl)carbamoyl]thiophen-2-yl}-1-benzothiophene-2-carboxamide, ... (4 entities in total)
Functional Keywordsproto-oncogene serine/threonine-protein kinase pim-1, structural genomics, structural genomics consortium, sgc, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
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Total number of polymer chains2
Total molecular weight37542.82
Authors
Primary citation
Godoi, P.H.C.,Santiago, A.S.,Fala, A.M.,Ramos, P.Z.,Sriranganadane, D.,Mascarello, A.,Segretti, N.,Azevedo, H.,Guimaraes, C.R.W.,Arruda, P.,Elkins, J.M.,Counago, R.M.
Human PIM1
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22620 0.4% 8.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution