6P6D

HUMAN IGG1 FC FRAGMENT, C239 INSERTION MUTANT

Summary for 6P6D

• Entry DOI: 10.2210/pdb6p6d/pdb
• Related: 5vgp
• Descriptor: IgG1 Fc fragment, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, ... (4 entities in total)
• Functional Keywords: antibody-drug conjugate, cysteine insertion mutant, cysteine disulfide adduct, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 54601.34

Authors

Gallagher, D.T.,Dimasi, N.,McCullough, C. (deposition date: 2019-06-03, release date: 2020-04-15, Last modification date: 2023-10-11)

• Primary citation: Gallagher, D.T.,McCullough, C.,Brinson, R.G.,Ahn, J.,Marino, J.P.,Dimasi, N.; Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions.; Pharmaceutics, 11:-, 2019; PubMed: 31640157; DOI: 10.3390/pharmaceutics11100546

Experimental method

X-RAY DIFFRACTION (2.31 Å)