8FV8
| E coli. CTP synthase in complex with dF-dCTP + ADP | 分子名称: | 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate), ADENOSINE-5'-DIPHOSPHATE, CTP synthase, ... | 著者 | Holyoak, T, McLeod, M.J, Tran, N. | 登録日 | 2023-01-18 | 公開日 | 2023-05-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate. Protein Sci., 32, 2023
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3W80
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8FVC
| E coli. CTP synthase in complex with dF-dCTP (potassium malonate + 5 mM MgCl2) | 分子名称: | 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate), CTP synthase, MALONIC ACID | 著者 | Holyoak, T, McLeod, M.J, Tran, N. | 登録日 | 2023-01-18 | 公開日 | 2023-05-24 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.281 Å) | 主引用文献 | A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate. Protein Sci., 32, 2023
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8FVD
| E coli. CTP synthase in complex with dF-dCTP (potassium malonate + 100 mM MgCl2) | 分子名称: | 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate), CTP synthase, MAGNESIUM ION, ... | 著者 | Holyoak, T, McLeod, M.J, Tran, N. | 登録日 | 2023-01-18 | 公開日 | 2023-05-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate. Protein Sci., 32, 2023
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8FVA
| E coli. CTP synthase in complex with F-araCTP | 分子名称: | 4-amino-1-{2-deoxy-2-fluoro-5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}pyrimidin-2(1H)-one, CTP synthase, MALONIC ACID, ... | 著者 | Holyoak, T, McLeod, M.J, Tran, N. | 登録日 | 2023-01-18 | 公開日 | 2023-05-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate. Protein Sci., 32, 2023
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1UBF
| MsREcA-ATPgS complex | 分子名称: | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, RecA | 著者 | Datta, S, Krishna, R, Ganesh, N, Chandra, N.R, Muniyappa, K, Vijayan, M. | 登録日 | 2003-04-04 | 公開日 | 2003-07-22 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Crystal Structures of Mycobacterium smegmatis RecA and Its Nucleotide Complexes J.BACTERIOL., 185, 2003
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8G04
| Structure of signaling thrombopoietin-MPL receptor complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombopoietin, Thrombopoietin receptor, ... | 著者 | Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C. | 登録日 | 2023-01-31 | 公開日 | 2023-08-30 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis. Cell, 186, 2023
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8FGX
| Cryo-EM structure of the STAR-0215 Fab in complex with active human plasma kallikrein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Plasma kallikrein light chain, STAR-0215 Heavy chain, ... | 著者 | Fuller, J.R, Biris, N, Bista, P. | 登録日 | 2022-12-13 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | 主引用文献 | STAR-0215 is a Novel, Long-Acting Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Potential Treatment of Hereditary Angioedema. J.Pharmacol.Exp.Ther., 387, 2023
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8FEC
| Structure of J-PKAc chimera complexed with Aplithianine derivative | 分子名称: | 6-[(6P)-6-(4-bromo-1-methyl-1H-imidazol-5-yl)-2,3-dihydro-4H-1,4-thiazin-4-yl]-7H-purine, DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha | 著者 | Du, L, Wilson, B.A.P, Li, N, Martinez Fiesco, J.A, Dalilian, M, Wang, D, Smith, E.A, Wamiru, A, Goncharova, E.I, Zhang, P, O'Keefe, B.R. | 登録日 | 2022-12-06 | 公開日 | 2023-10-18 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases. J.Nat.Prod., 86, 2023
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8FE2
| Structure of J-PKAc chimera complexed with Aplithianine A | 分子名称: | 6-[(6M)-6-(1-methyl-1H-imidazol-5-yl)-2,3-dihydro-4H-1,4-thiazin-4-yl]-9H-purine, DnaJ homolog subfamily B member 1, cAMP-dependent protein kinase catalytic subunit alpha, ... | 著者 | Du, L, Wilson, B.A.P, Li, N, Dalilian, M, Wang, D, Martinez Fiesco, J.A, Smith, E.A, Wamiru, A, Goncharova, E.I, Zhang, P, O'Keefe, B.R. | 登録日 | 2022-12-05 | 公開日 | 2023-10-18 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases. J.Nat.Prod., 86, 2023
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8FLI
| Cryo-EM structure of a group II intron immediately before branching | 分子名称: | Group II Intron, MAGNESIUM ION, Maturase reverse transcriptase | 著者 | Haack, D.B, Rudolfs, B.G, Zhang, C, Lyumkis, D, Toor, N. | 登録日 | 2022-12-21 | 公開日 | 2023-12-13 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural basis of branching during RNA splicing. Nat.Struct.Mol.Biol., 31, 2024
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8FHS
| Human L-type voltage-gated calcium channel Cav1.2 in the presence of amiodarone and sofosbuvir at 3.3 Angstrom resolution | 分子名称: | (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gao, S, Yao, X, Yan, N. | 登録日 | 2022-12-15 | 公開日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
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8T21
| Cryo-EM structure of mink variant Y453F trimeric spike protein | 分子名称: | Spike glycoprotein | 著者 | Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B. | 登録日 | 2023-06-05 | 公開日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
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8TAZ
| Cryo-EM structure of mink variant Y453F trimeric spike protein bound to one mink ACE2 receptors | 分子名称: | Angiotensin-converting enzyme, Spike glycoprotein | 著者 | Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Liang, B. | 登録日 | 2023-06-28 | 公開日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | 主引用文献 | Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
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8T22
| Cryo-EM structure of mink variant Y453F trimeric spike protein bound to one mink ACE2 receptors at downRBD conformation | 分子名称: | Angiotensin-converting enzyme, Spike glycoprotein | 著者 | Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B. | 登録日 | 2023-06-05 | 公開日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.83 Å) | 主引用文献 | Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
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8T20
| Cryo-EM structure of mink variant Y453F trimeric spike protein bound to two mink ACE2 receptors | 分子名称: | Angiotensin-converting enzyme, Spike glycoprotein | 著者 | Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B. | 登録日 | 2023-06-05 | 公開日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
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8T25
| Cryo-EM structure of the RBD-ACE2 interface of the SARS-CoV-2 trimeric spike protein bound to ACE2 receptor after local refinement at downRBD conformation. | 分子名称: | Angiotensin-converting enzyme, Spike glycoprotein | 著者 | Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B. | 登録日 | 2023-06-05 | 公開日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | 主引用文献 | Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
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8T23
| Cryo-EM structure of the RBD-ACE2 interface of the SARS-CoV-2 trimeric spike protein bound to ACE2 receptor after local refinement at upRBD conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... | 著者 | Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B. | 登録日 | 2023-06-05 | 公開日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
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8FOR
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8FMC
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8FMD
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8FOQ
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8FME
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8FOS
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8FW2
| Cryo-EM structure of full-length human NLRC4 inflammasome with C11 symmetry | 分子名称: | NLR family CARD domain-containing protein 4 | 著者 | Matico, R.E, Yu, X, Miller, R, Somani, S, Ricketts, M.D, Kumar, N, Steele, R.A, Medley, Q, Berger, S, Faustin, B, Sharma, S. | 登録日 | 2023-01-20 | 公開日 | 2024-01-03 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing. Nat.Struct.Mol.Biol., 31, 2024
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