8T25

Cryo-EM structure of the RBD-ACE2 interface of the SARS-CoV-2 trimeric spike protein bound to ACE2 receptor after local refinement at downRBD conformation.

Summary for 8T25

Entry DOI	10.2210/pdb8t25/pdb
EMDB information	40980
Descriptor	Angiotensin-converting enzyme, Spike glycoprotein (2 entities in total)
Functional Keywords	coronavirus, spike, ace2, mink, protein binding, viral protein
Biological source	Neovison vison More
Total number of polymer chains	2
Total formula weight	112745.75
Authors	Ahn, H.M.,Calderon, B.,Fan, X.,Gao, Y.,Horgan, N.,Zhou, B.,Liang, B. (deposition date: 2023-06-05, release date: 2023-10-25)
Primary citation	Ahn, H.,Calderon, B.M.,Fan, X.,Gao, Y.,Horgan, N.L.,Jiang, N.,Blohm, D.S.,Hossain, J.,Rayyan, N.W.K.,Osman, S.H.,Lin, X.,Currier, M.,Steel, J.,Wentworth, D.E.,Zhou, B.,Liang, B. Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95:e29163-e29163, 2023 Cited by PubMed: 37842796 DOI: 10.1002/jmv.29163 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.62 Å)

Structure validation