Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 39 件
1KDR
DownloadVisualize
BU of 1kdr by Molmil
CYTIDINE MONOPHOSPHATE KINASE FROM E.COLI IN COMPLEX WITH ARA-CYTIDINE MONOPHOSPHATE
分子名称: CYTIDYLATE KINASE, CYTOSINE ARABINOSE-5'-PHOSPHATE, SULFATE ION
著者Bertrand, T, Briozzo, P, Assairi, L, Ofiteru, A, Bucurenci, N, Munier-Lehmann, H, Golinelli-Pimpaneau, B, Barzu, O, Gilles, A.M.
登録日2001-11-13
公開日2002-01-22
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme.
J.Mol.Biol., 315, 2002
1KDT
DownloadVisualize
BU of 1kdt by Molmil
CYTIDINE MONOPHOSPHATE KINASE FROM E.COLI IN COMPLEX WITH 2',3'-DIDEOXY-CYTIDINE MONOPHOSPHATE
分子名称: 2',3'-DIDEOXYCYTIDINE-5'-MONOPHOSPHATE, CYTIDYLATE KINASE, SULFATE ION
著者Bertrand, T, Briozzo, P, Assairi, L, Ofiteru, A, Bucurenci, N, Munier-Lehmann, H, Golinelli-Pimpaneau, B, Barzu, O, Gilles, A.M.
登録日2001-11-13
公開日2002-01-22
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme.
J.Mol.Biol., 315, 2002
1KDP
DownloadVisualize
BU of 1kdp by Molmil
CYTIDINE MONOPHOSPHATE KINASE FROM E. COLI IN COMPLEX WITH 2'-DEOXY-CYTIDINE MONOPHOSPHATE
分子名称: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, CYTIDYLATE KINASE, SULFATE ION
著者Bertrand, T, Briozzo, P, Assairi, L, Ofiteru, A, Bucurenci, N, Munier-Lehmann, H, Golinelli-Pimpaneau, B, Barzu, O, Gilles, A.M.
登録日2001-11-13
公開日2002-01-22
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme.
J.Mol.Biol., 315, 2002
6YT1
DownloadVisualize
BU of 6yt1 by Molmil
Mtb TMK crystal structure in complex with compound 26
分子名称: 2-ethyl-~{N}-[[4-[4-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]piperidin-1-yl]phenyl]methyl]-1,2,3,5,6,7,8,8~{a}-octahydroimidazo[1,2-a]pyridine-3-carboxamide, CITRIC ACID, Thymidylate kinase
著者Merceron, R, De Munck, S, Jian, Y, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S.N.
登録日2020-04-23
公開日2020-09-02
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents.
Eur.J.Med.Chem., 206, 2020
7QEM
DownloadVisualize
BU of 7qem by Molmil
bacterial IMPDH chimera
分子名称: INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase
著者Labesse, G, Gelin, M, Gedeon, A, Haouz, A, Munier-Lehmann, H.
登録日2021-12-03
公開日2023-06-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.09 Å)
主引用文献Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases.
Protein Sci., 32, 2023
7QBJ
DownloadVisualize
BU of 7qbj by Molmil
bacterial IMPDH chimera
分子名称: Inosine-5'-monophosphate dehydrogenase
著者Labesse, G, Gelin, M, Munier-Lehmann, H, Gedeon, A, Haouz, A.
登録日2021-11-19
公開日2023-05-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases.
Protein Sci., 32, 2023
7QDX
DownloadVisualize
BU of 7qdx by Molmil
bacterial IMPDH chimera
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase, MAGNESIUM ION
著者Labesse, G, Gelin, M, Munier-Lehmann, H, Gedeon, A, Haouz, A.
登録日2021-11-30
公開日2023-06-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases.
Protein Sci., 32, 2023
4DQW
DownloadVisualize
BU of 4dqw by Molmil
Crystal Structure Analysis of PA3770
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, Inosine-5'-monophosphate dehydrogenase, ...
著者Labesse, G, Munier-Lehmann, H.
登録日2012-02-16
公開日2013-03-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献MgATP Regulates Allostery and Fiber Formation in IMPDHs.
Structure, 21, 2013
3NWY
DownloadVisualize
BU of 3nwy by Molmil
Structure and allosteric regulation of the uridine monophosphate kinase from Mycobacterium tuberculosis
分子名称: GUANOSINE-5'-TRIPHOSPHATE, URIDINE-5'-DIPHOSPHATE, Uridylate kinase
著者Labesse, G, Munier-Lehmann, H.
登録日2010-07-12
公開日2010-08-25
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation.
Nucleic Acids Res., 39, 2011
1P4S
DownloadVisualize
BU of 1p4s by Molmil
Solution structure of Mycobacterium tuberculosis adenylate kinase
分子名称: Adenylate kinase
著者Miron, S, Munier-Lehmann, H, Craescu, C.T.
登録日2003-04-24
公開日2004-01-20
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structural and Dynamic Studies on Ligand-Free Adenylate Kinase from Mycobacterium tuberculosis Revealed a Closed Conformation that Can Be Related to the Reduced Catalytic Activity.
Biochemistry, 43, 2004
6GK9
DownloadVisualize
BU of 6gk9 by Molmil
Inhibited structure of IMPDH from Pseudomonas aeruginosa
分子名称: (5~{S})-7-azanyl-5-(4-chlorophenyl)-2,4-bis(oxidanylidene)-1,5-dihydropyrano[2,3-d]pyrimidine-6-carbonitrile, Inosine-5'-monophosphate dehydrogenase, SULFATE ION
著者Labesse, G, Alexandre, T, Haouz, A, Munier-Lehmann, H.
登録日2018-05-18
公開日2019-02-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献First-in-class allosteric inhibitors of bacterial IMPDHs.
Eur J Med Chem, 167, 2019
6GJV
DownloadVisualize
BU of 6gjv by Molmil
apo-structure of IMPDH from Pseudomonas aeruginosa
分子名称: Inosine-5'-monophosphate dehydrogenase
著者Labesse, G, Haouz, A, Alexandre, T, Munier-Lehmann, H.
登録日2018-05-17
公開日2019-02-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献First-in-class allosteric inhibitors of bacterial IMPDHs.
Eur J Med Chem, 167, 2019
1G3U
DownloadVisualize
BU of 1g3u by Molmil
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (TMP)
分子名称: MAGNESIUM ION, SULFATE ION, THYMIDINE-5'-PHOSPHATE, ...
著者Li de la Sierra, I, Munier-Lehmann, H, Gilles, A.M, Barzu, O, Delarue, M.
登録日2000-10-25
公開日2001-10-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution.
J.Mol.Biol., 311, 2001
1N5J
DownloadVisualize
BU of 1n5j by Molmil
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE DIPHOSPHATE (TDP) AND THYMIDINE TRIPHOSPHATE (TTP) AT PH 5.4 (1.85 A RESOLUTION)
分子名称: MAGNESIUM ION, SULFATE ION, THYMIDINE-5'-DIPHOSPHATE, ...
著者Fioravanti, E, Haouz, A, Ursby, T, Munier-Lehmann, H, Delarue, M, Bourgeois, D.
登録日2002-11-06
公開日2003-04-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Mycobacterium tuberculosis Thymidylate Kinase: Structural Studies of Intermediates along the Reaction Pathway
J.Mol.Biol., 327, 2003
1N5I
DownloadVisualize
BU of 1n5i by Molmil
CRYSTAL STRUCTURE OF INACTIVE MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (TMP) AT PH 4.6 (RESOLUTION 1.85 A)
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CITRATE ANION, SULFATE ION, ...
著者Fioravanti, E, Haouz, A, Ursby, T, Munier-Lehmann, H, Delarue, M, Bourgeois, D.
登録日2002-11-06
公開日2003-04-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Mycobacterium tuberculosis Thymidylate Kinase: Structural Studies of Intermediates along the Reaction Pathway
J.Mol.Biol., 327, 2003
1N5K
DownloadVisualize
BU of 1n5k by Molmil
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE CRYSTALLIZED IN SODIUM MALONATE (RESOLUTION 2.1 A)
分子名称: ACETATE ION, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ...
著者Fioravanti, E, Haouz, A, Ursby, T, Munier-Lehmann, H, Delarue, M, Bourgeois, D.
登録日2002-11-06
公開日2003-04-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Mycobacterium tuberculosis Thymidylate Kinase: Structural Studies of Intermediates along the Reaction Pathway
J.Mol.Biol., 375, 2003
1N5L
DownloadVisualize
BU of 1n5l by Molmil
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE CRYSTALLIZED IN SODIUM MALONATE, AFTER CATALYSIS IN THE CRYSTAL (2.3 A RESOLUTION)
分子名称: ACETATE ION, DIPHOSPHATE, MAGNESIUM ION, ...
著者Fioravanti, E, Haouz, A, Ursby, T, Munier-Lehmann, H, Delarue, M, Bourgeois, D.
登録日2002-11-06
公開日2003-04-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Mycobacterium tuberculosis Thymidylate Kinase: Structural Studies of Intermediates along the Reaction Pathway
J.Mol.Biol., 375, 2003
1W2G
DownloadVisualize
BU of 1w2g by Molmil
Crystal Structure Of Mycobacterium Tuberculosis Thymidylate Kinase Complexed With Deoxythymidine (dT) (2.1 A Resolution)
分子名称: ACETATE ION, THYMIDINE, THYMIDYLATE KINASE TMK
著者Fioravanti, E, Adam, V, Munier-Lehmann, H, Bourgeois, D.
登録日2004-07-06
公開日2005-01-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Crystal Structure of Mycobacterium Tuberculosis Thymidylate Kinase in Complex with 3'-Azidodeoxythymidine Monophosphate Suggests a Mechanism for Competitive Inhibition
Biochemistry, 44, 2005
1W2H
DownloadVisualize
BU of 1w2h by Molmil
Crystal Structure Of Mycobacterium Tuberculosis Thymidylate Kinase Complexed With Azidothymidine Monophosphate (AZT-MP) (2.0 A Resolution)
分子名称: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ACETATE ION, THYMIDYLATE KINASE TMK
著者Fioravanti, E, Adam, V, Munier-Lehmann, H, Bourgeois, D.
登録日2004-07-06
公開日2005-01-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3'-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition.
Biochemistry, 44, 2005
2FEM
DownloadVisualize
BU of 2fem by Molmil
Mutant R188M of the Cytidine Monophosphate Kinase From E. Coli
分子名称: Cytidylate kinase
著者Ofiteru, A, Bucurenci, N, Alexov, E, Bertrand, T, Briozzo, P, Munier-Lehmann, H, Tourneux, L, Barzu, O, Gilles, A.M.
登録日2005-12-16
公開日2006-01-10
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase.
Febs J., 274, 2007
2FEO
DownloadVisualize
BU of 2feo by Molmil
Mutant R188M of The Cytidine Monophosphate Kinase from E. coli complexed with dCMP
分子名称: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, Cytidylate kinase, SULFATE ION
著者Ofiteru, A, Bucurenci, N, Alexov, E, Bertrand, T, Briozzo, P, Munier-Lehmann, H, Tourneux, L, Barzu, O, Gilles, A.M.
登録日2005-12-16
公開日2006-01-10
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase.
Febs J., 274, 2007
5NQ5
DownloadVisualize
BU of 5nq5 by Molmil
Mtb TMK crystal structure in complex with compound 1
分子名称: 5-methyl-1-[(3~{S})-1-[(3-phenoxyphenyl)methyl]piperidin-3-yl]pyrimidine-2,4-dione, Thymidylate kinase
著者Merceron, R, Song, L, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S.
登録日2017-04-19
公開日2018-03-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.
J. Med. Chem., 61, 2018
5NRQ
DownloadVisualize
BU of 5nrq by Molmil
Mtb TMK crystal structure in complex with compound 33
分子名称: 1-[1-[[5-(3-chloranylphenoxy)pyridin-3-yl]methyl]piperidin-4-yl]-5-methyl-pyrimidine-2,4-dione, CHLORIDE ION, Thymidylate kinase
著者Merceron, R, Song, L, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S.
登録日2017-04-25
公開日2018-08-08
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Mtb TMK crystal structure in complex with compound LS3112
To Be Published
5NR7
DownloadVisualize
BU of 5nr7 by Molmil
Mtb TMK crystal structure in complex with compound 43
分子名称: 1-[1-[[4-(3-chloranylphenoxy)quinolin-2-yl]methyl]piperidin-4-yl]-5-methyl-pyrimidine-2,4-dione, CHLORIDE ION, Thymidylate kinase
著者Merceron, R, Song, L, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S.
登録日2017-04-22
公開日2018-03-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.
J. Med. Chem., 61, 2018
5NRN
DownloadVisualize
BU of 5nrn by Molmil
Mtb TMK crystal structure in complex with compound 3
分子名称: 5-methyl-1-[1-[(6-phenoxypyridin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4-dione, CHLORIDE ION, Thymidylate kinase
著者Merceron, R, Song, L, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S.
登録日2017-04-25
公開日2018-08-08
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Mtb TMK crystal structure in complex with compound LS3080
To Be Published

 

12>

224201

件を2024-08-28に公開中

PDB statisticsPDBj update infoContact PDBjnumon