1W2H

Crystal Structure Of Mycobacterium Tuberculosis Thymidylate Kinase Complexed With Azidothymidine Monophosphate (AZT-MP) (2.0 A Resolution)

Summary for 1W2H

• Entry DOI: 10.2210/pdb1w2h/pdb
• Related: 1G3U 1GSI 1GTV 1MRN 1MRS 1N5I 1N5J 1N5K 1N5L 1W2G
• Descriptor: THYMIDYLATE KINASE TMK, 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ACETATE ION, ... (4 entities in total)
• Functional Keywords: transferase, mycobacterium tuberculosis, thymidylate kinase, azt, inhibition mechanism
• Biological source: MYCOBACTERIUM TUBERCULOSIS
• Total number of polymer chains: 2
• Total formula weight: 46543.85

Authors

Fioravanti, E.,Adam, V.,Munier-Lehmann, H.,Bourgeois, D. (deposition date: 2004-07-06, release date: 2005-01-12, Last modification date: 2023-12-13)

• Primary citation: Fioravanti, E.,Adam, V.,Munier-Lehmann, H.,Bourgeois, D.; The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3'-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition.; Biochemistry, 44:130-137, 2005; PubMed: 15628853; DOI: 10.1021/bi0484163

Experimental method

X-RAY DIFFRACTION (2 Å)