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PDB: 100 件
8UQE
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BU of 8uqe by Molmil
Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 26-residue linker (RING not modeled in density)
分子名称: E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E
著者Hu, Q, Botuyan, M.V, Mer, G.
登録日2023-10-23
公開日2024-01-17
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.562 Å)
主引用文献Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
3P8D
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BU of 3p8d by Molmil
Crystal structure of the second Tudor domain of human PHF20 (homodimer form)
分子名称: Medulloblastoma antigen MU-MB-50.72
著者Cui, G, Lee, J, Thompson, J.R, Botuyan, M.V, Mer, G.
登録日2010-10-13
公開日2011-06-22
最終更新日2012-09-26
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
Nat.Struct.Mol.Biol., 19, 2012
3PD7
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BU of 3pd7 by Molmil
Crystal Structure of the Sixth BRCT Domain of Human TopBP1
分子名称: DNA topoisomerase 2-binding protein 1
著者Lee, J, Xu, C, Cui, G, Thompson, J.R, Mer, G.
登録日2010-10-22
公開日2010-12-08
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.26 Å)
主引用文献Crystal Structure of the Sixth BRCT Domain of Human TopBP1
To be Published
6VE5
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BU of 6ve5 by Molmil
X-ray structure of human REV7 in complex with Shieldin3 (residues 41-74)
分子名称: Mitotic spindle assembly checkpoint protein MAD2B, SULFATE ION, Shieldin complex subunit 3
著者Cui, G, Botuyan, M.V, Mer, G.
登録日2019-12-28
公開日2021-01-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta.
J.Biol.Chem., 297, 2021
3SD4
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BU of 3sd4 by Molmil
Crystal structure of the first Tudor domain of human PHF20
分子名称: PHD finger protein 20
著者Cui, G, Botuyan, M.V, Thompson, J.R, Mer, G.
登録日2011-06-08
公開日2011-06-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.928 Å)
主引用文献PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
Nat.Struct.Mol.Biol., 19, 2012
6MXY
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BU of 6mxy by Molmil
Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC3351
分子名称: N-[3-(tert-butylamino)propyl]-3-(trifluoromethyl)benzamide, PHOSPHATE ION, TP53-binding protein 1
著者Cui, G, Botuyan, M.V, Mer, G.
登録日2018-10-31
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.624 Å)
主引用文献An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
6MXZ
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BU of 6mxz by Molmil
Structure of 53BP1 Tudor domains in complex with small molecule UNC3474
分子名称: FORMIC ACID, N-[3-(tert-butylamino)propyl]-3-(propan-2-yl)benzamide, TP53-binding protein 1
著者Cui, G, Botuyan, M.V, Schuller, D.J, Mer, G.
登録日2018-10-31
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
6MY0
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BU of 6my0 by Molmil
Structure of 53BP1 Tandem Tudor domains with E1549P and D1550N mutations
分子名称: TP53-binding protein 1
著者Cui, G, Botuyan, M.V, Mer, G.
登録日2018-10-31
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
6MXX
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BU of 6mxx by Molmil
Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC2991
分子名称: FORMIC ACID, N-[3-(tert-butylamino)propyl]-3-iodobenzamide, PHOSPHATE ION, ...
著者Cui, G, Botuyan, M.V, Mer, G.
登録日2018-10-31
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.298 Å)
主引用文献An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
2QQR
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BU of 2qqr by Molmil
JMJD2A hybrid tudor domains
分子名称: JmjC domain-containing histone demethylation protein 3A, SULFATE ION
著者Lee, J, Botuyan, M.V, Mer, G.
登録日2007-07-26
公開日2007-12-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor.
Nat.Struct.Mol.Biol., 15, 2008
2QQS
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BU of 2qqs by Molmil
JMJD2A tandem tudor domains in complex with a trimethylated histone H4-K20 peptide
分子名称: JmjC domain-containing histone demethylation protein 3A, METHYLATED HISTONE H4 PEPTIDE
著者Lee, J, Botuyan, M.V, Mer, G.
登録日2007-07-26
公開日2007-12-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor.
Nat.Struct.Mol.Biol., 15, 2008
3L1X
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BU of 3l1x by Molmil
Crystal Structure of U-box Domain of Human E4B Ubiquitin Ligase
分子名称: Ubiquitin conjugation factor E4 B
著者Benirschke, R, Thompson, J.R, Mer, G.
登録日2009-12-14
公開日2010-05-05
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4.
Structure, 18, 2010
3KTF
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BU of 3ktf by Molmil
Structure of the N-terminal BRCT domain of human microcephalin (MCPH1).
分子名称: CHLORIDE ION, Microcephalin
著者Singh, N, Heroux, A, Thompson, J.R, Mer, G.
登録日2009-11-25
公開日2009-12-15
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of N-terminal BRCT domain of human microcephalin (MCPH1)
To be Published
3L1Z
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BU of 3l1z by Molmil
Crystal structure of the U-BOX domain of human E4B ubiquitin ligase in complex with UBCH5C E2 ubiquitin conjugating enzyme
分子名称: Ubiquitin conjugation factor E4 B, Ubiquitin-conjugating enzyme E2 D3
著者Benirschke, R, Thompson, J.R, Mer, G.
登録日2009-12-14
公開日2010-05-05
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.17 Å)
主引用文献Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4.
Structure, 18, 2010
3L1Y
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BU of 3l1y by Molmil
Crystal structure of human UBC4 E2 conjugating enzyme
分子名称: Ubiquitin-conjugating enzyme E2 D2
著者Benirschke, R, Thompson, J.R, Mer, G.
登録日2009-12-14
公開日2010-05-05
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4.
Structure, 18, 2010
2B02
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BU of 2b02 by Molmil
Crystal Structure of ARNT PAS-B Domain
分子名称: Aryl hydrocarbon receptor nuclear translocator
著者Lee, J, Botuyan, M.V, Nomine, Y, Ohh, M, Thompson, J.R, Mer, G.
登録日2005-09-12
公開日2006-10-24
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal Structure and Binding Properties of ARNT PAS-B Heterodimerization Domain
To be Published
2FHD
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BU of 2fhd by Molmil
Crystal structure of Crb2 tandem tudor domains
分子名称: DNA repair protein rhp9/CRB2, PHOSPHATE ION
著者Lee, J, Botuyan, M.V, Thompson, J.R, Mer, G.
登録日2005-12-23
公開日2007-01-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.
Cell(Cambridge,Mass.), 127, 2006
2ETX
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BU of 2etx by Molmil
Crystal Structure of MDC1 Tandem BRCT Domains
分子名称: Mediator of DNA damage checkpoint protein 1
著者Wasielewski, E, Kim, Y, Joachimiak, A, Thompson, J.R, Mer, G.
登録日2005-10-27
公開日2005-11-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Molecular Basis for the Association of Microcephalin (MCPH1) Protein with the Cell Division Cycle Protein 27 (Cdc27) Subunit of the Anaphase-promoting Complex.
J.Biol.Chem., 287, 2012
2G3R
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BU of 2g3r by Molmil
Crystal Structure of 53BP1 tandem tudor domains at 1.2 A resolution
分子名称: SULFATE ION, Tumor suppressor p53-binding protein 1
著者Lee, J, Botuyan, M.V, Thompson, J.R, Mer, G.
登録日2006-02-20
公開日2007-01-02
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair.
Cell(Cambridge,Mass.), 127, 2006
3PA6
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BU of 3pa6 by Molmil
Structure of the N-terminal BRCT domain of human microcephalin (MCPH1)
分子名称: CHLORIDE ION, Microcephalin
著者Singh, N, Heroux, A, Thompson, J.R, Mer, G.
登録日2010-10-18
公開日2010-12-08
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure of the N-terminal BRCT domain of human microcephalin (MCPH1)
To be Published
3Q68
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BU of 3q68 by Molmil
Structure of the Vps75-Rtt109 histone chaperone-lysine acetyltransferase complex (Full-length proteins in space group P212121)
分子名称: Histone acetyltransferase RTT109, Vacuolar protein sorting-associated protein 75 (VPS75)
著者Su, D, Thompson, J.R, Mer, G.
登録日2010-12-30
公開日2011-03-23
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.705 Å)
主引用文献Structure and histone binding properties of the Vps75-Rtt109 chaperone-lysine acetyltransferase complex.
J.Biol.Chem., 286, 2011
3Q66
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BU of 3q66 by Molmil
Structure of the Vps75-Rtt109 histone chaperone-lysine acetyltransferase complex (Full-length proteins in space group P6122)
分子名称: Histone acetyltransferase RTT109, SULFATE ION, Vacuolar protein sorting-associated protein 75
著者Su, D, Thompson, J.R, Mer, G.
登録日2010-12-30
公開日2011-03-23
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.705 Å)
主引用文献Structure and histone binding properties of the Vps75-Rtt109 chaperone-lysine acetyltransferase complex.
J.Biol.Chem., 286, 2011
3SZM
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BU of 3szm by Molmil
STRUCTURE OF HUMAN MICROCEPHALIN (MCPH1) TANDEM BRCT DOMAINS IN COMPLEX WITH A GAMMA-H2AX PHOSPHOPEPTIDE
分子名称: Histone H2A.x, Microcephalin
著者Singh, N, Thompson, J.R, Mer, G.
登録日2011-07-19
公開日2011-11-30
最終更新日2012-09-19
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.
Proc.Natl.Acad.Sci.USA, 109, 2012
3T1N
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BU of 3t1n by Molmil
Structure of human MICROCEPHALIN (MCPH1) TANDEM BRCT domains in complex with a CDC27 phosphopeptide
分子名称: Cdc27 peptide, Microcephalin
著者Singh, N, Thompson, J.R, Mer, G.
登録日2011-07-22
公開日2011-11-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular Basis for the Association of Microcephalin (MCPH1) Protein with the Cell Division Cycle Protein 27 (Cdc27) Subunit of the Anaphase-promoting Complex.
J.Biol.Chem., 287, 2012
3U3Z
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BU of 3u3z by Molmil
Structure of human microcephalin (MCPH1) tandem BRCT domains in complex with an H2A.X peptide phosphorylated at Ser139 and Tyr142
分子名称: GLYCEROL, Histone H2A.X peptide, Microcephalin
著者Singh, N, Thompson, J.R, Heroux, A, Mer, G.
登録日2011-10-06
公開日2012-07-25
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.
Proc.Natl.Acad.Sci.USA, 109, 2012

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