4GTC
| T. Maritima FDTS (E144R mutant) plus FAD | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase thyX | 著者 | Mathews, I.I, Lesley, S.A, Kohen, A, Prabhakar, A. | 登録日 | 2012-08-28 | 公開日 | 2012-10-17 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Folate binding site of flavin-dependent thymidylate synthase. Proc.Natl.Acad.Sci.USA, 109, 2012
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5HD8
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7SMJ
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9BC3
| Transglutaminase 2 - Alternate state | 分子名称: | CALCIUM ION, HB-225 (gluten peptidomimetic TG2 inhibitor), Protein-glutamine gamma-glutamyltransferase 2 | 著者 | Mathews, I.I, Sewa, A.S, Khosla, C. | 登録日 | 2024-04-07 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state. Proc.Natl.Acad.Sci.USA, 121, 2024
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3G4A
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3G4C
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9BC2
| Transglutaminase 2 - Open State | 分子名称: | CHLORIDE ION, HB-225 (gluten peptidomimetic TG2 inhibitor), Protein-glutamine gamma-glutamyltransferase 2, ... | 著者 | Mathews, I.I, Sewa, A, Khosla, C. | 登録日 | 2024-04-07 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state. Proc.Natl.Acad.Sci.USA, 121, 2024
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6APG
| Trans-acting transferase from Disorazole synthase with malonate | 分子名称: | CALCIUM ION, DisD protein, GLYCEROL, ... | 著者 | Mathews, I.I, Lyubimov, A.Y, Soltis, S.M, Khosla, C, Robbins, T, Cohen, A.E. | 登録日 | 2017-08-17 | 公開日 | 2018-04-04 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography. Biochemistry, 56, 2017
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6APF
| Trans-acting transferase from Disorazole synthase complexed with Citrate. | 分子名称: | CITRIC ACID, DisD protein, GLYCEROL, ... | 著者 | Mathews, I.I, Lyubimov, A, Soltis, M, Khosla, C, Cohen, A, Robbins, T. | 登録日 | 2017-08-17 | 公開日 | 2018-04-04 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography. Biochemistry, 56, 2017
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8VTJ
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7SEH
| Glucose-6-phosphate 1-dehydrogenase (K403QdLtL) | 分子名称: | Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Mathews, I.I, Garcia, A.A, Wakatsuki, S, Mochly-Rosen, D. | 登録日 | 2021-09-30 | 公開日 | 2022-08-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants. J.Biol.Chem., 298, 2022
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7SEI
| Glucose-6-phosphate 1-dehydrogenase (K403Q) | 分子名称: | Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Mathews, I.I, Garcia, A.A, Wakatsuki, S, Mochly-Rosen, D. | 登録日 | 2021-09-30 | 公開日 | 2022-08-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | 主引用文献 | Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants. J.Biol.Chem., 298, 2022
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7T2V
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7T2T
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3N0C
| TM0449 mutant crystal grown by hanging drop method | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase thyX | 著者 | Mathews, I.I. | 登録日 | 2010-05-13 | 公開日 | 2011-05-25 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Diffraction study of protein crystals grown in cryoloops and micromounts. J.Appl.Crystallogr., 43, 2010
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3N0B
| TM0449 mutant crystals grown in loops/micromounts | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase thyX | 著者 | Mathews, I.I. | 登録日 | 2010-05-13 | 公開日 | 2011-05-25 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Diffraction study of protein crystals grown in cryoloops and micromounts. J.Appl.Crystallogr., 43, 2010
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6MLK
| Structure of Thioesterase from DEBS with a thioesterase-specific antibody | 分子名称: | 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6, CHLORIDE ION, ... | 著者 | Mathews, I.I, Li, X, Khosla, C. | 登録日 | 2018-09-27 | 公開日 | 2018-10-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase. Biochemistry, 57, 2018
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8EUA
| Structure of SARS-CoV2 PLpro bound to a covalent inhibitor | 分子名称: | Papain-like protease nsp3, SULFATE ION, ZINC ION, ... | 著者 | Mathews, I.I, Pokhrel, S, Wakatsuki, S. | 登録日 | 2022-10-18 | 公開日 | 2023-04-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2. Nat Commun, 14, 2023
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4GTE
| T. Maritima FDTS (E144R mutant) with FAD and Folate | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, N-({4-[(6aR)-3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]phenyl}carbonyl)-L-glutamic acid, Thymidylate synthase thyX | 著者 | Mathews, I.I, Lesley, S.A, Kohen, A, Prabhakar, A. | 登録日 | 2012-08-28 | 公開日 | 2012-10-17 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Folate binding site of flavin-dependent thymidylate synthase. Proc.Natl.Acad.Sci.USA, 109, 2012
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4GT9
| T. Maritima FDTS with FAD, dUMP and Folate. | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Mathews, I.I, Lesley, S.A, Kohen, A. | 登録日 | 2012-08-28 | 公開日 | 2012-10-17 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | 主引用文献 | Folate binding site of flavin-dependent thymidylate synthase. Proc.Natl.Acad.Sci.USA, 109, 2012
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4GTD
| T. Maritima FDTS (E144R mutant) with FAD and dUMP | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase thyX | 著者 | Mathews, I.I, Lesley, S.A, Kohen, A, Prabhakar, A. | 登録日 | 2012-08-28 | 公開日 | 2012-10-17 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Folate binding site of flavin-dependent thymidylate synthase. Proc.Natl.Acad.Sci.USA, 109, 2012
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4KAR
| Crystal structure of FDTS (TM0449) mutant (H53D) with FAD | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, NONAETHYLENE GLYCOL, Thymidylate synthase | 著者 | Mathews, I.I. | 登録日 | 2013-04-22 | 公開日 | 2014-03-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design. J Bioterror Biodef, Suppl 12, 2013
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4GTB
| T. Maritima FDTS with FAD, dUMP, and Raltitrexed. | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Mathews, I.I, Lesley, S.A, Kohen, A. | 登録日 | 2012-08-28 | 公開日 | 2012-10-17 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Folate binding site of flavin-dependent thymidylate synthase. Proc.Natl.Acad.Sci.USA, 109, 2012
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4GTL
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4GTA
| T. Maritima FDTS with FAD, dUMP, and Folinic Acid | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Mathews, I.I, Lesley, S.A, Kohen, A. | 登録日 | 2012-08-28 | 公開日 | 2012-10-17 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Folate binding site of flavin-dependent thymidylate synthase. Proc.Natl.Acad.Sci.USA, 109, 2012
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