7T2V

SARS CoV2 Mpro C145S mutant

Summary for 7T2V

Entry DOI	10.2210/pdb7t2v/pdb
Descriptor	3C-Like Protease (2 entities in total)
Functional Keywords	sars-cov2 2c-like protease, mpro, 2clpro, c145s mutation, hydrolase
Biological source	Severe acute respiratory syndrome coronavirus 2
Total number of polymer chains	4
Total formula weight	142257.58
Authors	Mathews, I.I.,Hameedi, M.A.,Wakatsuki, S. (deposition date: 2021-12-06, release date: 2022-09-14, Last modification date: 2024-04-03)
Primary citation	Hameedi, M.A.,T Prates, E.,Garvin, M.R.,Mathews, I.I.,Amos, B.K.,Demerdash, O.,Bechthold, M.,Iyer, M.,Rahighi, S.,Kneller, D.W.,Kovalevsky, A.,Irle, S.,Vuong, V.Q.,Mitchell, J.C.,Labbe, A.,Galanie, S.,Wakatsuki, S.,Jacobson, D. Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro. Nat Commun, 13:5285-5285, 2022 Cited by PubMed: 36075915 DOI: 10.1038/s41467-022-32922-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.47 Å)

Structure validation