4GTE
T. Maritima FDTS (E144R mutant) with FAD and Folate
Summary for 4GTE
| Entry DOI | 10.2210/pdb4gte/pdb |
| Descriptor | Thymidylate synthase thyX, FLAVIN-ADENINE DINUCLEOTIDE, N-({4-[(6aR)-3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]phenyl}carbonyl)-L-glutamic acid, ... (4 entities in total) |
| Functional Keywords | flavin-dependent thymidylate synthase, tm0449, e144r mutant, folate, transferase |
| Biological source | Thermotoga maritima |
| Total number of polymer chains | 4 |
| Total formula weight | 114184.12 |
| Authors | Mathews, I.I.,Lesley, S.A.,Kohen, A.,Prabhakar, A. (deposition date: 2012-08-28, release date: 2012-10-17, Last modification date: 2023-09-13) |
| Primary citation | Koehn, E.M.,Perissinotti, L.L.,Moghram, S.,Prabhakar, A.,Lesley, S.A.,Mathews, I.I.,Kohen, A. Folate binding site of flavin-dependent thymidylate synthase. Proc.Natl.Acad.Sci.USA, 109:15722-15727, 2012 Cited by PubMed: 23019356DOI: 10.1073/pnas.1206077109 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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