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PDB: 50 件
7QTQ
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Structure of Native, iodinated bovine thyroglobulin solved on strepavidin affinity grids.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Thyroglobulin, ...
著者Marechal, N, Weitz, J.C, Serrano, B.P, Zhang, X.
登録日2022-01-15
公開日2022-05-04
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Formation of thyroid hormone revealed by a cryo-EM structure of native bovine thyroglobulin.
Nat Commun, 13, 2022
7QRD
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BU of 7qrd by Molmil
Crystal structure of mouse CARM1 in complex with histone H3_10-25
分子名称: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol, 1,2-ETHANEDIOL, Histone-arginine methyltransferase CARM1, ...
著者Marechal, N, Cura, V, Troffer-Charlier, N, Bonnefond, L, Cavarelli, J.
登録日2022-01-11
公開日2022-12-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献CARM1 Transition State Mimics
To Be Published
7QPH
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BU of 7qph by Molmil
Crystal structure of mouse CARM1 in complex with histone H3_22-31 K27 acetylated
分子名称: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol, 1,2-ETHANEDIOL, Histone H3 22-31 K27 acetylated, ...
著者Marechal, N, Cura, V, Troffer-Charlier, N, Bonnefond, L, Cavarelli, J.
登録日2022-01-04
公開日2023-01-18
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献CARM1 Transition State Mimics
To Be Published
7OS4
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BU of 7os4 by Molmil
Crystal structure of mouse CARM1 in complex with histone H3_13-31 K18
分子名称: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol, Histone H3.1, Histone-arginine methyltransferase CARM1
著者Marechal, N, Cura, V, Troffer-Charlier, N, Bonnefond, L, Cavarelli, J.
登録日2021-06-07
公開日2021-10-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献Structural Studies Provide New Insights into the Role of Lysine Acetylation on Substrate Recognition by CARM1 and Inform the Design of Potent Peptidomimetic Inhibitors.
Chembiochem, 22, 2021
7OKP
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BU of 7okp by Molmil
Crystal structure of mouse CARM1 in complex with histone H3_13-22 K18 acetylated
分子名称: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol, Histone H3.3, Histone-arginine methyltransferase CARM1, ...
著者Marechal, N, Cura, V, Troffer-Charlier, N, Bonnefond, L, Cavarelli, J.
登録日2021-05-18
公開日2021-10-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Studies Provide New Insights into the Role of Lysine Acetylation on Substrate Recognition by CARM1 and Inform the Design of Potent Peptidomimetic Inhibitors.
Chembiochem, 22, 2021
7PUQ
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CARM1 in complex with EML982
分子名称: 1,2-ETHANEDIOL, Histone-arginine methyltransferase CARM1, methyl 6-[4-[[~{N}-[3-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]propyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate
著者Marechal, N, Cura, V, Troffer-Charlier, N, Bonnefond, L, Cavarelli, J.
登録日2021-09-30
公開日2022-04-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
J.Med.Chem., 65, 2022
7PPY
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CARM1 in complex with EML709
分子名称: 1,2-ETHANEDIOL, Histone-arginine methyltransferase CARM1, methyl 6-[4-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate
著者Marechal, N, Cura, V, Bonnefond, L, Troffer-Charlier, N, Cavarelli, J.
登録日2021-09-15
公開日2022-04-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
J.Med.Chem., 65, 2022
7PV6
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CARM1 in complex with EML734
分子名称: 1,2-ETHANEDIOL, Histone-arginine methyltransferase CARM1, TETRAETHYLENE GLYCOL, ...
著者Marechal, N, Cura, V, Troffer-Charlier, N, Bonnefond, L, Cavarelli, J.
登録日2021-10-01
公開日2022-04-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
J.Med.Chem., 65, 2022
7PU8
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BU of 7pu8 by Molmil
CARM1 in complex with EML980
分子名称: 1,2-ETHANEDIOL, Histone-arginine methyltransferase CARM1, methyl 6-[4-[[N-[2-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate
著者Marechal, N, Cura, V, Troffer-Charlier, N, Bonnefond, L, Cavarelli, J.
登録日2021-09-28
公開日2022-04-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
J.Med.Chem., 65, 2022
7PPQ
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BU of 7ppq by Molmil
CARM1 in complex with EML736
分子名称: 1,2-ETHANEDIOL, Histone-arginine methyltransferase CARM1, methyl 6-[5-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]pentylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate
著者Marechal, N, Cura, V, Bonnefond, L, Troffer-Charlier, N, Cavarelli, J.
登録日2021-09-14
公開日2022-04-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
J.Med.Chem., 65, 2022
7PUC
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CARM1 in complex with EML981
分子名称: 1,2-ETHANEDIOL, Histone-arginine methyltransferase CARM1, methyl 6-[4-[[~{N}-[(~{E})-3-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]prop-2-enyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate
著者Marechal, N, Cura, V, Bonnefond, L, Troffer-Charlier, N, Cavarelli, J.
登録日2021-09-29
公開日2022-04-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
J.Med.Chem., 65, 2022
5LGP
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BU of 5lgp by Molmil
Crystal structure of mouse CARM1 in complex with ligand P1C3s
分子名称: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-propyl-oxolane-3,4-diol, 1,2-ETHANEDIOL, Histone-arginine methyltransferase CARM1, ...
著者Marechal, N, Troffer-Charlier, N, Cura, V, Bonnefond, L, Cavarelli, J.
登録日2016-07-08
公開日2017-03-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5LGQ
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BU of 5lgq by Molmil
Crystal structure of mouse CARM1 in complex with ligand P2C3s
分子名称: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-propyl-oxolane-3,4-diol, 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, ...
著者Marechal, N, Troffer-Charlier, N, Cura, V, Bonnefond, L, Cavarelli, J.
登録日2016-07-08
公開日2017-03-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5LGS
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BU of 5lgs by Molmil
Crystal structure of mouse CARM1 in complex with ligand P2C3u
分子名称: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol, 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, ...
著者Marechal, N, Troffer-Charlier, N, Cura, V, Bonnefond, L, Cavarelli, J.
登録日2016-07-08
公開日2017-03-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5LGR
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BU of 5lgr by Molmil
Crystal structure of mouse CARM1 in complex with ligand P1C3u
分子名称: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol, 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, ...
著者Marechal, N, Troffer-Charlier, N, Cura, V, Bonnefond, L, Cavarelli, J.
登録日2016-07-08
公開日2017-03-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5K8W
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BU of 5k8w by Molmil
Crystal structure of mouse CARM1 in complex with inhibitor U2
分子名称: 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, 9-(7-{[amino(iminio)methyl]amino}-5,6,7-trideoxy-beta-D-ribo-heptofuranosyl)-9H-purin-6-amine, ...
著者Cura, V, Marechal, N, Mailliot, J, Troffer-Charlier, N, Hassenboehler, P, Wurtz, J.M, Bonnefond, L, Cavarelli, J.
登録日2016-05-31
公開日2017-06-21
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of mouse CARM1 in complex with inhibitor U2
To Be Published
5K8X
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BU of 5k8x by Molmil
Crystal structure of mouse CARM1 in complex with inhibitor U3
分子名称: 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE, ...
著者Cura, V, Marechal, N, Mailliot, J, Troffer-Charlier, N, Hassenboehler, P, Wurtz, J.M, Bonnefond, L, Cavarelli, J.
登録日2016-05-31
公開日2017-06-21
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.991 Å)
主引用文献Crystal structure of mouse CARM1 in complex with inhibitor U3
To Be Published
5K8V
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BU of 5k8v by Molmil
Crystal Structure of Mus musculus Protein Arginine Methyltransferase 4 (CARM1 130-487) with CP1
分子名称: 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, ...
著者Cura, V, Marechal, N, Mailliot, J, Troffer-Charlier, N, Hassenboehler, P, Wurtz, J.M, Bonnefond, L, Cavarelli, J.
登録日2016-05-31
公開日2016-11-09
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.
FEBS J., 284, 2017
8PJD
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BU of 8pjd by Molmil
Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 94-445
分子名称: ACETATE ION, Protein arginine N-methyltransferase 2, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Cura, V, Troffer-Charlier, N, Marechal, N, Bonnefond, L, Cavarelli, J.
登録日2023-06-23
公開日2024-07-10
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 94-445
To Be Published
5NTC
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BU of 5ntc by Molmil
Crystal structure of mouse CARM1 in complex with inhibitor SA0678
分子名称: 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE, ...
著者Cura, V, Marechal, N, Mailliot, J, Troffer-Charlier, N, Hassenboehler, P, Wurtz, J.M, Bonnefond, L, Cavarelli, J.
登録日2017-04-27
公開日2018-05-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal structure of mouse CARM1 in complex with inhibitor SA0678
To Be Published
5TBJ
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BU of 5tbj by Molmil
Crystal structure of mouse CARM1 in complex with inhibitor LH1452
分子名称: 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, ...
著者Cura, V, Marechal, N, Troffer-Charlier, N, Halby, L, Arimondo, P, Bonnefond, L, Cavarelli, J.
登録日2016-09-12
公開日2017-09-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors.
Philos.Trans.R.Soc.Lond.B Biol.Sci., 373, 2018
5TBI
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BU of 5tbi by Molmil
Crystal structure of mouse CARM1 in complex with inhibitor LH1427
分子名称: 1,2-ETHANEDIOL, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 4-[2-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]ethylamino]-1-(methoxymethyl)pyrimidin-2-one, ...
著者Cura, V, Marechal, N, Troffer-Charlier, N, Halby, L, Arimondo, P, Bonnefond, L, Cavarelli, J.
登録日2016-09-12
公開日2017-09-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.294 Å)
主引用文献Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors.
Philos.Trans.R.Soc.Lond.B Biol.Sci., 373, 2018
5TBH
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BU of 5tbh by Molmil
Crystal structure of mouse CARM1 in complex with inhibitor LH1236
分子名称: (2~{R})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]amino]-2-azanyl-butanoic acid, 1,2-ETHANEDIOL, 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE, ...
著者Cura, V, Marechal, N, Troffer-Charlier, N, Halby, L, Arimondo, P, Bonnefond, L, Cavarelli, J.
登録日2016-09-12
公開日2017-09-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.341 Å)
主引用文献Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors.
Philos.Trans.R.Soc.Lond.B Biol.Sci., 373, 2018
8BVA
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BU of 8bva by Molmil
Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 in complex with RSF1_114-126
分子名称: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol, L(+)-TARTARIC ACID, POTASSIUM ION, ...
著者Cura, V, Troffer-Charlier, N, Marechal, N, Bonnefond, L, Cavarelli, J.
登録日2022-12-02
公開日2023-12-13
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 in complex with RSF1_114-126
To Be Published
8C1J
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Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 in complex with RSF1_18-30
分子名称: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol, Protein arginine N-methyltransferase 2, RNA-binding protein Rsf1-like
著者Cura, V, Troffer-Charlier, N, Marechal, N, Bonnefond, L, Cavarelli, J.
登録日2022-12-20
公開日2024-01-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 in complex with RSF1_18-30
To Be Published

 

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